| Predose infant nevirapine concentration with the two-dose intrapartum neonatal nevirapine regimen: association with timing of maternal intrapartum nevirapine dose. | |
| | |
MedLine Citation:
|
PMID: 12794547 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To evaluate cord blood and predose nevirapine concentrations in infants exposed to the two-dose intrapartum neonatal nevirapine regimen. METHODS: The authors obtained plasma samples for nevirapine assay from cord blood and just prior to the 48-hours to 72-hours after birth neonatal nevirapine dose from a subset of infants participating in PACTG 316, a randomized, placebo-controlled trial of the two-dose intrapartum neonatal nevirapine regimen added to standard antiretroviral therapy. RESULTS: Nevirapine concentrations were measured in 109 cord blood samples and 149 predose samples. Cord blood nevirapine concentrations were below the target concentration of 100 ng/mL (10-times the in vitro IC(50) of nevirapine against wild-type HIV) in eight (7%) of 109 infants (95% confidence interval [CI], 3%-14%); the concentrations in six of these infants were below the assay limit of quantitation. Predose infant nevirapine concentrations were below 100 ng/mL in 23 (15%) of 149 infants (95% CI, 10%-22%); the concentrations in 13 of these infants were below the assay limit of quantitation. Lower predose nevirapine concentrations were associated with lower cord blood concentrations and a shorter interval between maternal dosing and delivery. All but one of the infants with predose nevirapine concentrations below the assay limit of quantitation were born less than 2 hours after maternal dosing. CONCLUSION: Infants born less than 2 hours after maternal nevirapine dosing during labor should receive a dose of nevirapine immediately after birth in addition to the standard infant dose at 48 to 72 hours. |
| | |
Authors:
|
Mark Mirochnick; Alejandro Dorenbaum; Suzette Blanchard; Coleen K Cunningham; Richard D Gelber; Lynne Mofenson; Mary Culnane; John L Sullivan |
Related Documents
:
|
23547797 - Neonatal mortality in sudan: analysis of the sudan household survey, 2010. 18572747 - Cord blood lipids in infants born to hiv-1-infected women treated with combination anti... 8248367 - Metabolic correlates of behaviour in the newborn infant. 20154067 - Association of hla-a, -b and -drb1 genotype with birthweight and cd34+ cell content: an... 18838467 - Prevention and treatment of invasive fungal infection in very low birthweight infants. 23547797 - Neonatal mortality in sudan: analysis of the sudan household survey, 2010. |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of acquired immune deficiency syndromes (1999) Volume: 33 ISSN: 1525-4135 ISO Abbreviation: J. Acquir. Immune Defic. Syndr. Publication Date: 2003 Jun |
Date Detail:
|
Created Date: 2003-06-09 Completed Date: 2003-08-29 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 100892005 Medline TA: J Acquir Immune Defic Syndr Country: United States |
Other Details:
|
Languages: eng Pagination: 153-6 Citation Subset: IM; X |
Affiliation:
|
Boston University School of Medicine, Boston Medical Center, 91 Concord Street, 6th Floor, Boston, MA 02118, USA. mark.m@bu.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Anti-HIV Agents / administration & dosage, pharmacokinetics* Bahamas Brazil Double-Blind Method Europe Female Fetal Blood / metabolism HIV Infections / blood, drug therapy*, metabolism HIV-1* Humans Infant, Newborn Nevirapine / administration & dosage, pharmacokinetics* Pregnancy Pregnancy Complications, Infectious / blood, drug therapy*, metabolism United States |
| Chemical | |
Reg. No./Substance:
|
0/Anti-HIV Agents; 129618-40-2/Nevirapine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pretreatment of chronic active hepatitis C in patients coinfected with HIV and hepatitis C virus red...
Next Document: Complementary and alternative medicine use and substitution for conventional therapy by HIV-infected...