Document Detail

Predominant usage of distinct T-cell receptor V beta regions by epidermotropic T cells in psoriasis.
MedLine Citation:
PMID:  8000704     Owner:  NLM     Status:  MEDLINE    
To investigate the role of T cells in psoriasis, we analyzed the T-cell receptor (TCR) repertoire in peripheral blood lymphocytes (PBLs) and in skin lesions of 9 patients with chronic plaque-stage psoriasis by means of immunohistochemistry. An extended panel of monoclonal antibodies detecting 11 different V beta families was employed in this study. In the peripheral blood, no predominant TCR V beta expression was detected and interindividual differences were small. Skin-infiltrating T cells showed only marginal differences in the TCR V beta usage when compared with PBLs. However, in 3 patients the intraepidermal infiltrate comprised up to 40% of T cells expressing a TCR V beta region which was virtually absent in the peripheral blood and the dermal infiltrate. Thus, although the TCR V beta usage of skin-infiltrating T cells showed little difference compared to PBLs, several cases exhibited a significant increase of epidermotrophic T cells using one particular V beta region.
W H Boehncke; C Küenzlen; T M Zollner; V Mielke; W Sterry
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental dermatology     Volume:  3     ISSN:  0906-6705     ISO Abbreviation:  Exp. Dermatol.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1995-01-26     Completed Date:  1995-01-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9301549     Medline TA:  Exp Dermatol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  161-3     Citation Subset:  IM    
Department of Dermatology, University of Ulm, Germany.
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MeSH Terms
Epidermis / immunology*
Psoriasis / immunology*
Receptors, Antigen, T-Cell, alpha-beta / biosynthesis*
T-Lymphocytes / immunology*
Reg. No./Substance:
0/Receptors, Antigen, T-Cell, alpha-beta

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