Document Detail

Predominant expression of Brn-2 in the postmitotic neurons of the developing mouse neocortex.
MedLine Citation:
PMID:  9106466     Owner:  NLM     Status:  MEDLINE    
The expression of Brn-2, a central nervous systems (CNS)-specific POU domain transcription factor, in the developing mouse neocortex was examined with an anti-Brn-2 antibody. Brn-2 protein was first detected in CNS on embryonic day (E) 11.5, and remained strong until E15.5. From E11.5 to postnatal day (P) 0, a high level of Brn-2 expression was observed in the subventricular zone, the intermediate zone, and the outer layer of the neocortex, but not in the ventricular zone. In the double-staining experiments, most of the Brn-2 positive cells were also positive for NCAM-H, an adhesion molecule specific to post-mitotic neurons. Furthermore, BrdU-labeling experiments demonstrated the presence of Brn-2 protein exclusively in postmitotic cells. These results indicated that, in the developing neocortex, Brn-2 expression is up-regulated after the final cell division. Therefore, this transcription factor may be involved in the migration and/or maturation process of the immature neuronal cells.
K Hagino-Yamagishi; Y Saijoh; M Ikeda; M Ichikawa; R Minamikawa-Tachino; H Hamada
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  752     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-06-23     Completed Date:  1997-06-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  261-8     Citation Subset:  IM    
Department of the Ultrastructural Research, Tokyo Metropolitan Institute of Medical Science, Bunkyo-ku, Japan.
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MeSH Terms
Cell Line
Cerebral Cortex / embryology*
Embryo, Mammalian / metabolism*,  physiology
Embryonic and Fetal Development
Homeodomain Proteins
Intermediate Filament Proteins / metabolism
Mice / embryology
Nerve Tissue Proteins*
Neural Cell Adhesion Molecules / metabolism
Neuroglia / metabolism
Neurons / metabolism*
POU Domain Factors
Transcription Factors / metabolism*
Reg. No./Substance:
0/Homeodomain Proteins; 0/Intermediate Filament Proteins; 0/Nerve Tissue Proteins; 0/Neural Cell Adhesion Molecules; 0/POU Domain Factors; 0/Transcription Factors; 0/nestin; 0/transcription factor Brn-2

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