| Predominant expression of Brn-2 in the postmitotic neurons of the developing mouse neocortex. | |
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MedLine Citation:
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PMID: 9106466 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The expression of Brn-2, a central nervous systems (CNS)-specific POU domain transcription factor, in the developing mouse neocortex was examined with an anti-Brn-2 antibody. Brn-2 protein was first detected in CNS on embryonic day (E) 11.5, and remained strong until E15.5. From E11.5 to postnatal day (P) 0, a high level of Brn-2 expression was observed in the subventricular zone, the intermediate zone, and the outer layer of the neocortex, but not in the ventricular zone. In the double-staining experiments, most of the Brn-2 positive cells were also positive for NCAM-H, an adhesion molecule specific to post-mitotic neurons. Furthermore, BrdU-labeling experiments demonstrated the presence of Brn-2 protein exclusively in postmitotic cells. These results indicated that, in the developing neocortex, Brn-2 expression is up-regulated after the final cell division. Therefore, this transcription factor may be involved in the migration and/or maturation process of the immature neuronal cells. |
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Authors:
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K Hagino-Yamagishi; Y Saijoh; M Ikeda; M Ichikawa; R Minamikawa-Tachino; H Hamada |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain research Volume: 752 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1997 Mar |
Date Detail:
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Created Date: 1997-06-23 Completed Date: 1997-06-23 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 261-8 Citation Subset: IM |
Affiliation:
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Department of the Ultrastructural Research, Tokyo Metropolitan Institute of Medical Science, Bunkyo-ku, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line Cerebral Cortex / embryology* Embryo, Mammalian / metabolism*, physiology Embryonic and Fetal Development Homeodomain Proteins Immunohistochemistry Intermediate Filament Proteins / metabolism Mice / embryology Mitosis* Nerve Tissue Proteins* Neural Cell Adhesion Molecules / metabolism Neuroglia / metabolism Neurons / metabolism* POU Domain Factors Transcription Factors / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Homeodomain Proteins; 0/Intermediate Filament Proteins; 0/Nerve Tissue Proteins; 0/Neural Cell Adhesion Molecules; 0/POU Domain Factors; 0/Transcription Factors; 0/nestin; 0/transcription factor Brn-2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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