Document Detail


Predominant effect of A-type natriuretic peptide on reduction of oxidative stress during the treatment of patients with heart failure.
MedLine Citation:
PMID:  17587708     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Oxidative stress plays an important role in the pathogenesis of heart failure and was investigated in the present study of the role of exogenous A-type natriuretic peptide (ANP) in the patients with heart failure and in cultured neonatal rat cardiomyocytes. METHODS AND RESULTS: The first protocol was to examine if an infusion of human ANP (carperitide) changed serum levels of TRX (thioredoxin) during the treatment of patients with heart failure compared with conventional therapy using furosemide. Protocol 2 investigated whether ANP had a direct antioxidant action on the failing heart by measuring TRX gene expression and reactive oxygen species (ROS) production in cultured neonatal rat cardiomyocytes. In Protocol 1, 8 patients were treated with only an intravenous bolus of furosemide and 11 patients with only an intravenous infusion of carperitide for 24 h. Serum TRX levels significantly decreased at 4 h (p<0.03) and at 24 h (p<0.05) in the carperitide group, whereas they decreased slightly but were not significantly different in the furosemide group. In Protocol 2, it was found that a low dose of exogenous ANP of 10(-9) mol/L significantly suppressed TRX expression and ROS production in cardiomyocytes. CONCLUSION: Carperitide infusion has a predominantly antioxidant action, in addition to improving the hemodynamics of patients with acute heart failure. Furthermore, carperitide infusion should have a direct antioxidant effect on the failing heart.
Authors:
Makoto Shono; Michihiro Yoshimura; Masafumi Nakayama; Megumi Yamamuro; Koji Abe; Satoru Suzuki; Yuji Mizuno; Seigo Sugiyama; Yoshihiko Saito; Kazuwa Nakao; Hirofumi Yasue; Hisao Ogawa
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  71     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-25     Completed Date:  2007-08-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1040-6     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Animals
Antioxidants / pharmacology,  therapeutic use
Atrial Natriuretic Factor / pharmacology*,  therapeutic use*
Cardiac Output, Low / blood,  drug therapy*,  physiopathology
Cells, Cultured
Diuretics / pharmacology,  therapeutic use
Dose-Response Relationship, Drug
Female
Furosemide / pharmacology,  therapeutic use
Gene Expression Regulation / drug effects
Humans
Male
Middle Aged
Myocytes, Cardiac / drug effects,  metabolism
Oxidative Stress / drug effects*,  physiology
Rats
Rats, Wistar
Reactive Oxygen Species / metabolism
Thioredoxins / genetics,  metabolism
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Diuretics; 0/NPPA protein, human; 0/Reactive Oxygen Species; 52500-60-4/Thioredoxins; 54-31-9/Furosemide; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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