| Predominant effect of A-type natriuretic peptide on reduction of oxidative stress during the treatment of patients with heart failure. | |
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MedLine Citation:
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PMID: 17587708 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Oxidative stress plays an important role in the pathogenesis of heart failure and was investigated in the present study of the role of exogenous A-type natriuretic peptide (ANP) in the patients with heart failure and in cultured neonatal rat cardiomyocytes. METHODS AND RESULTS: The first protocol was to examine if an infusion of human ANP (carperitide) changed serum levels of TRX (thioredoxin) during the treatment of patients with heart failure compared with conventional therapy using furosemide. Protocol 2 investigated whether ANP had a direct antioxidant action on the failing heart by measuring TRX gene expression and reactive oxygen species (ROS) production in cultured neonatal rat cardiomyocytes. In Protocol 1, 8 patients were treated with only an intravenous bolus of furosemide and 11 patients with only an intravenous infusion of carperitide for 24 h. Serum TRX levels significantly decreased at 4 h (p<0.03) and at 24 h (p<0.05) in the carperitide group, whereas they decreased slightly but were not significantly different in the furosemide group. In Protocol 2, it was found that a low dose of exogenous ANP of 10(-9) mol/L significantly suppressed TRX expression and ROS production in cardiomyocytes. CONCLUSION: Carperitide infusion has a predominantly antioxidant action, in addition to improving the hemodynamics of patients with acute heart failure. Furthermore, carperitide infusion should have a direct antioxidant effect on the failing heart. |
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Authors:
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Makoto Shono; Michihiro Yoshimura; Masafumi Nakayama; Megumi Yamamuro; Koji Abe; Satoru Suzuki; Yuji Mizuno; Seigo Sugiyama; Yoshihiko Saito; Kazuwa Nakao; Hirofumi Yasue; Hisao Ogawa |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 71 ISSN: 1346-9843 ISO Abbreviation: Circ. J. Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-06-25 Completed Date: 2007-08-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 1040-6 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Animals Antioxidants / pharmacology, therapeutic use Atrial Natriuretic Factor / pharmacology*, therapeutic use* Cardiac Output, Low / blood, drug therapy*, physiopathology Cells, Cultured Diuretics / pharmacology, therapeutic use Dose-Response Relationship, Drug Female Furosemide / pharmacology, therapeutic use Gene Expression Regulation / drug effects Humans Male Middle Aged Myocytes, Cardiac / drug effects, metabolism Oxidative Stress / drug effects*, physiology Rats Rats, Wistar Reactive Oxygen Species / metabolism Thioredoxins / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Diuretics; 0/NPPA protein, human; 0/Reactive Oxygen Species; 52500-60-4/Thioredoxins; 54-31-9/Furosemide; 85637-73-6/Atrial Natriuretic Factor |
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