Document Detail

Predominant breast-feeding from birth to six months is associated with fewer gastrointestinal infections and increased risk for iron deficiency among infants.
MedLine Citation:
PMID:  18641197     Owner:  NLM     Status:  MEDLINE    
Iron deficiency (ID) is prevalent among infants world-wide and may be more likely among infants born to women living in disadvantaged environments. A strategy to address ID in this context is to feed iron-fortified formula, but this may create risk for gastrointestinal (GI) infection. Our objective was to investigate the relationship between infant feeding practices, iron status, and likelihood of a GI infection in the first 6 mo of life. We conducted a prospective study at a public hospital in Guadalajara, Mexico. Healthy women who gave birth to a healthy term infant were eligible to participate. Each month, mothers (n = 154) provided information on infant feeding methods and symptoms of GI infection. At 6 mo of age, infants' iron status was assessed [hemoglobin (Hb) and serum ferritin concentration]. When compared with nonpredominantly breast-fed [partially breast-feeding (PBF) and formula feeding (FF) combined], predominantly breast-fed (PRBF) infants to 6 mo had a lower incidence of GI infection from 0-6 mo [18 vs. 33%; P = 0.04; adjusted odds ratio (OR) = 0.4; 95% CI = 0.2, 1.0] but a higher risk for ID (serum ferritin < 12 microg/L) at 6 mo (22 vs. 4%; P = 0.001; adjusted OR = 9.2; 95% CI = 2.3, 37.0). Anemia (Hb < 110 g/L) prevalence did not differ among feeding groups (13% for PRBF, 19% for PBF, and 4% for FF; P = 0.09). In this low-income population, our results suggest that PRBF should be promoted and the risk for ID managed using public health and nutrition strategies.
Eva C Monterrosa; Edward A Frongillo; Edgar M Vásquez-Garibay; Enrique Romero-Velarde; Linda M Casey; Noreen D Willows
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of nutrition     Volume:  138     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-21     Completed Date:  2008-09-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1499-504     Citation Subset:  IM    
Department of Agricultural, Food, and Nutritional Sciences, University of Alberta, T6G 2P5 Edmonton, Canada.
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MeSH Terms
Anemia, Iron-Deficiency / epidemiology,  etiology*,  prevention & control
Breast Feeding* / adverse effects
Gastrointestinal Diseases / prevention & control*
Infant Formula / chemistry
Infant Nutritional Physiological Phenomena
Infant, Newborn
Iron, Dietary / administration & dosage
Mexico / epidemiology
Prospective Studies
Risk Factors
Reg. No./Substance:
0/Iron, Dietary

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