Document Detail

Predominance of rhinovirus in the nose of symptomatic and asymptomatic infants.
MedLine Citation:
PMID:  14641606     Owner:  NLM     Status:  MEDLINE    
Respiratory infections in infancy may protect against developing Th2-mediated allergic disease (hygiene hypothesis). To estimate the relative contribution of particular viruses to the development of the immune system and allergic disease, we investigated longitudinally the prevalence of respiratory viral infections in infants. One hundred and twenty-six healthy infants were included in this prospective birth cohort study in their first year of life. Physical examination was performed and nasal brush samples were taken during routine visits every 6 months and during an upper respiratory tract infection (URTI) (sick visits). The prevalence of respiratory viral infections in infants with URTI, infants with rhinitis without general malaise and infants without nasal symptoms was studied. Rhinovirus was the most prevalent pathogen during URTI and rhinitis in 0- to 2-year-old infants ( approximately 40%). During URTI, also respiratory syncytial virus ( approximately 20%) and coronavirus ( approximately 10%) infections were found, which were rarely detected in infants with rhinitis. Surprisingly, in 20% of infants who did not present with nasal symptoms, rhinovirus infections were also detected. During routine visits at 12 months, a higher prevalence of rhinovirus infections was found in infants who attended day-care compared with those who did not. We did not observe a relation between breast-feeding or smoking by one or both parents and the prevalence of rhinovirus infections. The parental history of atopy was not related to the prevalence of rhinovirus infection, indicating that the genetic risk of allergic disease does not seem to increase the chance of rhinovirus infections. In conclusion, rhinovirus infection is the most prevalent respiratory viral infection in infants. It may therefore affect the maturation of the immune system and the development of allergic disease considerably.
Inesz van Benten; Laurens Koopman; Bert Niesters; Wim Hop; Barbara van Middelkoop; Leon de Waal; Kees van Drunen; Albert Osterhaus; Herman Neijens; Wytske Fokkens
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology     Volume:  14     ISSN:  0905-6157     ISO Abbreviation:  Pediatr Allergy Immunol     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-12-03     Completed Date:  2004-03-12     Revised Date:  2008-05-28    
Medline Journal Info:
Nlm Unique ID:  9106718     Medline TA:  Pediatr Allergy Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  363-70     Citation Subset:  IM    
Department of Otorhinolaryngology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
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MeSH Terms
Age Factors
Child Day Care Centers
Child Welfare
Child, Preschool
Coronavirus Infections / epidemiology,  virology
Cytomegalovirus Infections / epidemiology,  virology
Dermatitis, Atopic / epidemiology,  virology
Environmental Exposure
Follow-Up Studies
Genetic Predisposition to Disease / epidemiology
Infant Welfare
Infant, Newborn
Logistic Models
Netherlands / epidemiology
Picornaviridae Infections / epidemiology,  virology*
Predictive Value of Tests
Prospective Studies
Respiratory Syncytial Virus Infections / epidemiology,  virology
Respiratory Tract Infections / epidemiology,  virology*
Risk Factors
Severity of Illness Index
Statistics as Topic

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