| Predominance of CD8+ T lymphocytes among periglomerular infiltrating cells and link to the prognosis of class III and class IV lupus nephritis. | |
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MedLine Citation:
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PMID: 17599764 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Recent studies have revealed a potential implication of CD8+ T lymphocytes in the pathogenesis of systemic lupus erythematosus (SLE) through their ability to induce tissue damage. The aim of the present study was to analyze the localization of CD8+ cells in the kidneys of patients with class III and class IV lupus nephritis and to establish correlations with histologic, biologic, and clinical features of SLE. METHODS: Twenty-five consecutive SLE patients with class III or class IV lupus nephritis were enrolled. Phenotype analyses of blood lymphocytes and renal immunohistochemistry studies were performed. RESULTS: CD8+ T cells were the predominant kidney-infiltrating subset of cells. The mean +/- SD numbers of CD8+ T cells and CD4+ T cells were 66.2 +/- 65.2/mm(2) and 19.3 +/- 29.4/mm(2), respectively. There was a significant correlation between the percentage of blood CD3+,CD8+,DR+ cells and the total number of renal CD8+ T cells (r = 0.42, P = 0.039). Renal CD8+ T cell infiltration correlated well with the renal activity index (r = 0.63, P = 0.0007) and with high serum creatinine levels (r = 0.75, P = 0.0001). This CD8+ T cell infiltrate, which was predominantly in the periglomerular area, was correlated with cellular crescents and Bowman's capsule rupture and was associated with a poor response after conventional induction therapy. CONCLUSION: CD8+ T lymphocytes infiltrate the periglomerular area in patients with severe (class III and class IV) lupus nephritis and are linked to a poor outcome after induction therapy. These results reveal a new potential effector pathway operant in lupus nephritis. |
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Authors:
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Lionel Couzi; Pierre Merville; Colette Deminière; Jean-François Moreau; Christian Combe; Jean-Luc Pellegrin; Jean-François Viallard; Patrick Blanco |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Arthritis and rheumatism Volume: 56 ISSN: 0004-3591 ISO Abbreviation: Arthritis Rheum. Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-07-31 Completed Date: 2007-09-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370605 Medline TA: Arthritis Rheum Country: United States |
Other Details:
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Languages: eng Pagination: 2362-70 Citation Subset: AIM; IM |
Affiliation:
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CHU, and UMR-CNRS 5164, Université Victor Segalen Bordeaux 2, Bordeaux, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Biopsy CD8-Positive T-Lymphocytes / immunology* Female Hematuria / immunology, pathology Humans Kidney / immunology, pathology Kidney Glomerulus / immunology*, pathology Lupus Erythematosus, Systemic / pathology Lupus Nephritis / immunology*, pathology Lymphocyte Count Male Nephrotic Syndrome / immunology, pathology Prognosis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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