| Prednisone induces anxiety and glial cerebral changes in rats. | |
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MedLine Citation:
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PMID: 11708428 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess whether prednisone (PDN) produces anxiety and/or cerebral glial changes in rats. METHODS: Male Wistar rats were studied and 3 groups were formed (8 rats per group). The moderate-dose group received 5 mg/kg/day PDN released from a subcutaneous implant. In the high-dose group, implants containing PDN equivalent to 60 mg/kg/day were applied. In the control group implants contained no PDN. Anxiety was assessed using an open field and elevated plus-maze devices. The number of cells and cytoplasmic transformation of astrocytes and microglia cells were assessed by immunohistochemical analyses. RESULTS: Anxiety was documented in both groups of PDN treated rats compared with controls. The magnitude of transformation of the microglia assessed by the number of intersections was significantly higher in the PDN groups than in controls in the prefrontal cortex (moderate-dose, 24.1; high-dose, 23.6; controls 18.7; p < 0.01) and striatum (moderate-dose 25.6; high-dose 26.3; controls 18.9; p < 0.01), but not in hippocampus. The number of stained microglia cells was significantly higher in the PDN treated groups in the prefrontal cortex than in controls (moderate-dose, 29.1; high-dose, 28.4; control, 17.7 cells per field; p < 0.01). Stained microglia cells were significantly more numerous striatum and hippocampus in the high-dose group compared to controls. CONCLUSION: Subacute exposure to PDN induced anxiety and reactivity of microglia. The relevance of these features for patients using PDN remains to be elucidated. |
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Authors:
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O Gonzalez-Perez; C Ramos-Remus; J Garcia-Estrada; S Luquin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of rheumatology Volume: 28 ISSN: 0315-162X ISO Abbreviation: J. Rheumatol. Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-11-15 Completed Date: 2002-04-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: Canada |
Other Details:
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Languages: eng Pagination: 2529-34 Citation Subset: IM |
Affiliation:
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Department of Rheumatology of the Centro Medico Nacional de Occidente, IMSS, Guadalajara, Mexico. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anxiety / chemically induced* Astrocytes / drug effects, metabolism, pathology Cerebral Cortex / drug effects*, pathology Corpus Striatum / drug effects, pathology Exploratory Behavior / drug effects Glucocorticoids / adverse effects* Hippocampus / drug effects, pathology Immunoenzyme Techniques Male Neuroglia / chemistry, drug effects*, pathology Prednisone / adverse effects* Prefrontal Cortex / drug effects*, pathology Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 53-03-2/Prednisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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