| Prednisone dosage and pregnancy outcome in renal allograft recipients. | |
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MedLine Citation:
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PMID: 9141008 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The literature contains reports of 2309 pregnancies in some 1600 women who have undergone renal transplantation. Certain pre-pregnancy factors, especially hypertension, renal graft dysfunction, short interval between transplant and pregnancy, and high immunosuppressive drug dosage, appear to increase the neonatal risks. METHOD: We describe the outcome of 42 pregnancies in 27 allograft recipients at Rabin Medical Center (Beilinson Campus) in Israel during the last 8 years. All were treated with combination immunosuppression regimens. RESULTS: The average interval from transplantation to conception was 3.7 +/- 0.4 years (2 months to 9 years). Rejection episodes occurred in 37% prior to pregnancy but in none during or immediately after pregnancy. Twenty-eight percent of the pregnancies ended in therapeutic or spontaneous abortions, and 29 of the 30 deliveries ended in a live birth. The prematurity rate (63%) was similar to that described in the literature for this patient group. Renal deterioration was evident in seven women (26%) within 2 years after delivery. Use of 7.5 mg/d prednisone (vs. 10 mg/d) before pregnancy was observed as the most significant preconception parameter related to better pregnancy outcome. A long interval from transplantation to conception and lack of pre-existing hypertension were also significant. CONCLUSION: The better pregnancy outcome associated with lower prednisone dosage is probably related to the fact that the patients selected to receive the low-dose regimen have had a longer and less complicated post-transplantation course. |
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Authors:
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J Bar; B Fisch; C Wittenberg; I Gelerenter; G Boner; M Hod |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Volume: 12 ISSN: 0931-0509 ISO Abbreviation: Nephrol. Dial. Transplant. Publication Date: 1997 Apr |
Date Detail:
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Created Date: 1997-07-18 Completed Date: 1997-07-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8706402 Medline TA: Nephrol Dial Transplant Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 760-3 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Rabin Medical Center, Peath Tiqva, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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etiology Adult Cesarean Section Female Fetal Growth Retardation / etiology Humans Immunosuppressive Agents / administration & dosage*, adverse effects* Infant, Newborn Kidney Transplantation / adverse effects, immunology, physiology* Pre-Eclampsia / etiology Prednisone / administration & dosage*, adverse effects* Pregnancy Pregnancy Outcome Risk Factors Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 53-03-2/Prednisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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