| Prednisolone plus low-dose aspirin improves the implantation rate in women with autoimmune conditions who are undergoing in vitro fertilization. | |
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MedLine Citation:
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PMID: 9848293 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the effect of prednisolone plus low-dose aspirin (PSL/LDA) in women with autoimmune conditions who were enrolled in an IVF-ET program. DESIGN: A retrospective clinical study. SETTING: In vitro fertilization unit, Niigata University Hospital, Niigata, Japan. PATIENT(S): Three hundred seven women who underwent IVF-ET between January 1996 and December 1997. INTERVENTION(S): Prednisolone (10 mg/d) and aspirin (81 mg/d) were administered to the women with autoantibodies who chose to participate. MAIN OUTCOME MEASURE(S): Pregnancy and implantation rates with IVF-ET. RESULT(S): Women undergoing IVF who had positive antinuclear antibodies, with or without antiphospholipid antibodies, had significantly lower pregnancy and implantation rates than did women without autoantibodies (14.8% versus 21.7% and 6.8% versus 10.4%, respectively). The administration of PSL/LDA to women with antinuclear antibodies significantly improved the outcome of IVF-ET (40.6% pregnancy rate and 20.3% implantation rate). CONCLUSION(S): A high proportion of women who are undergoing IVF-ET have autoantibodies, which are associated with poor IVF outcomes. The administration of PSL/LDA to these women may improve their implantation rate. |
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Authors:
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I Hasegawa; Y Yamanoto; M Suzuki; H Murakawa; T Kurabayashi; K Takakuwa; K Tanaka |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Fertility and sterility Volume: 70 ISSN: 0015-0282 ISO Abbreviation: Fertil. Steril. Publication Date: 1998 Dec |
Date Detail:
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Created Date: 1998-12-22 Completed Date: 1998-12-22 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1044-8 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Niigata University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antibodies, Antinuclear / blood Antibodies, Antiphospholipid / blood Aspirin / therapeutic use* Autoimmune Diseases / drug therapy* Dose-Response Relationship, Drug Drug Therapy, Combination Embryo Implantation* Embryo Transfer* Female Fertilization in Vitro* Humans Prednisolone / therapeutic use* Pregnancy Pregnancy Rate* Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antinuclear; 0/Antibodies, Antiphospholipid; 50-24-8/Prednisolone; 50-78-2/Aspirin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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