Document Detail

Prednisolone plus low-dose aspirin improves the implantation rate in women with autoimmune conditions who are undergoing in vitro fertilization.
MedLine Citation:
PMID:  9848293     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the effect of prednisolone plus low-dose aspirin (PSL/LDA) in women with autoimmune conditions who were enrolled in an IVF-ET program. DESIGN: A retrospective clinical study. SETTING: In vitro fertilization unit, Niigata University Hospital, Niigata, Japan. PATIENT(S): Three hundred seven women who underwent IVF-ET between January 1996 and December 1997. INTERVENTION(S): Prednisolone (10 mg/d) and aspirin (81 mg/d) were administered to the women with autoantibodies who chose to participate. MAIN OUTCOME MEASURE(S): Pregnancy and implantation rates with IVF-ET. RESULT(S): Women undergoing IVF who had positive antinuclear antibodies, with or without antiphospholipid antibodies, had significantly lower pregnancy and implantation rates than did women without autoantibodies (14.8% versus 21.7% and 6.8% versus 10.4%, respectively). The administration of PSL/LDA to women with antinuclear antibodies significantly improved the outcome of IVF-ET (40.6% pregnancy rate and 20.3% implantation rate). CONCLUSION(S): A high proportion of women who are undergoing IVF-ET have autoantibodies, which are associated with poor IVF outcomes. The administration of PSL/LDA to these women may improve their implantation rate.
I Hasegawa; Y Yamanoto; M Suzuki; H Murakawa; T Kurabayashi; K Takakuwa; K Tanaka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  70     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1998-12-22     Completed Date:  1998-12-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1044-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Niigata University School of Medicine, Japan.
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MeSH Terms
Antibodies, Antinuclear / blood
Antibodies, Antiphospholipid / blood
Aspirin / therapeutic use*
Autoimmune Diseases / drug therapy*
Dose-Response Relationship, Drug
Drug Therapy, Combination
Embryo Implantation*
Embryo Transfer*
Fertilization in Vitro*
Prednisolone / therapeutic use*
Pregnancy Rate*
Retrospective Studies
Reg. No./Substance:
0/Antibodies, Antinuclear; 0/Antibodies, Antiphospholipid; 50-24-8/Prednisolone; 50-78-2/Aspirin

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