Document Detail

Prednisolone and flurbiprofen drops to maintain mydriasis during phacoemulsification cataract surgery.
MedLine Citation:
PMID:  14709299     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To compare the effects on the pupil of pretreatment with prednisolone 1% eyedrops, flurbiprofen 0.03% eyedrops, and sodium chloride 0.9% eyedrops in patients having phacoemulsification cataract surgery. SETTING: Christopher Home Eye Unit, Royal Albert Edward Infirmary, Wigan, United Kingdom. METHODS: One hundred thirty-six white patients having phacoemulsification with no history of eye disease, antiinflammatory medication, or diabetes were enrolled in this prospective randomized double-blind study. Patients were allocated to receive flurbiprofen 0.03%, prednisolone 1%, or sodium chloride 0.9% (placebo) eyedrops at 30-minute intervals beginning 2 hours before surgery. All patients received cyclopentolate 1% and phenylephrine 2.5% drops preoperatively and epinephrine 1:10(6) intraoperatively in the intraocular irrigating solution. The pupil diameter was measured from a television screen at the preset magnification of the operating microscope immediately before the incision, at the end of nucleus emulsification, at the end of irrigation/aspiration (I/A), and at the end of surgery. One hundred twelve patients with a baseline pupil diameter of at least 6.0 mm who had uneventful phacoemulsification were analyzed. RESULTS: The baseline pupil diameters were statistically similar. An analysis of variance did not reveal an overall significant mydriasis-maintaining effect of prednisolone or flurbiprofen compared to the placebo at any stage of surgery (P =.16 to.37). The 95% confidence interval showed flurbiprofen to be superior to prednisolone at the end of surgery. According to the paired t test, the reduction from the baseline at the end of I/A in the prednisolone group (P =.051) and at the end of surgery in the flurbiprofen group (P =.22) was not significant. CONCLUSION: In the presence of epinephrine in the intraocular irrigating solution, both prednisolone 1% and flurbiprofen 0.03% failed to maintain mydriasis at the crucial steps of nuclear emulsification and cortical I/A.
M Yusuf Shaikh; J Simon Mars; Chris J Heaven
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of cataract and refractive surgery     Volume:  29     ISSN:  0886-3350     ISO Abbreviation:  J Cataract Refract Surg     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-01-07     Completed Date:  2004-02-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8604171     Medline TA:  J Cataract Refract Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2372-7     Citation Subset:  IM    
Christopher Home Eye Unit, Royal Albert Edward Infirmary, Wigan, United Kingdom.
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MeSH Terms
Cyclooxygenase Inhibitors / administration & dosage*
Double-Blind Method
Drug Evaluation
Flurbiprofen / administration & dosage*
Glucocorticoids / administration & dosage*
Lens Implantation, Intraocular
Mydriatics / administration & dosage
Ophthalmic Solutions / administration & dosage
Prednisolone / administration & dosage*,  analogs & derivatives*
Prospective Studies
Pupil / drug effects*
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 0/Glucocorticoids; 0/Mydriatics; 0/Ophthalmic Solutions; 50-24-8/Prednisolone; 5104-49-4/Flurbiprofen; 52-21-1/prednisolone acetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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