| Prednisolone-α-cyclodextrin-star PEG polypseudorotaxanes with controlled drug delivery properties. | |
| | |
MedLine Citation:
|
PMID: 20859603 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The reaction of α-amino-ω-methoxypoly(ethylene glycol) [M = 5000] or star α-amino-poly(ethylene glycol) [M = 20 000] with hemiesters of prednisolone dicarboxylic acids (succinic, glutaric, adipic, phthalic acid) has been used to prepare the corresponding conjugates. The rate of esterase catalyzed hydrolysis of the conjugates is controlled by the molecular mass of poly(ethylene glycol) and the length of the linker between prednisolone and poly(ethylene glycol) (τ(1/2)∼ 5-0.5 h). The enzymatic hydrolysis proceeds most rapidly at conjugates with linkers derived from adipic and phthalic acids. The synthesized conjugates form polypseudorotaxanes with α-cyclodextrin which were characterized by 2D NOESY NMR spectra, powder X-ray diffraction patterns and in one case also by STM microscopy. In the case of the polypseudorotaxane having the linker derived from adipic acid, the enzymatic release proceeds ca. five times slower in comparison with the rate of prednisolone release from the corresponding conjugate. The rate of prednisolone release from the carrier can be controlled by three factors: character of the linker between the polymeric carrier and prednisolone, the molecular mass of poly(ethylene glycol) and complex formation with α-cyclodextrin. The synthesized polypseudorotaxanes represent new promising transport systems intended for targeted release of prednisolone in transplanted liver. |
| | |
Authors:
|
Eliška Bílková; Miloš Sedlák; Bohuslav Dvořák; Karel Ventura; Petr Knotek; Ludvík Beneš |
Related Documents
:
|
20877843 - Synthesis and self-assembly of poly(3-hexylthiophene)-block-poly(acrylic acid). 6442993 - Differential effect of amino acid residues on the stability of double helices formed fr... 18563463 - Experimental design for the production of tensio-active agent by candida lipolytica. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-22 |
Journal Detail:
|
Title: Organic & biomolecular chemistry Volume: 8 ISSN: 1477-0539 ISO Abbreviation: Org. Biomol. Chem. Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-10 Completed Date: 2011-02-01 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101154995 Medline TA: Org Biomol Chem Country: England |
Other Details:
|
Languages: eng Pagination: 5423-30 Citation Subset: IM |
Affiliation:
|
Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 532 10 Pardubice, Czech Republic. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cyclodextrins
/
chemistry* Microscopy, Scanning Tunneling Molecular Structure Poloxamer / chemistry* Polyethylene Glycols / chemistry* Prednisolone / chemistry* Rotaxanes / chemistry* alpha-Cyclodextrins / chemistry* |
| Chemical | |
Reg. No./Substance:
|
0/Cyclodextrins; 0/Polyethylene Glycols; 0/Rotaxanes; 0/alpha-Cyclodextrins; 0/pseudopolyrotaxane; 10016-20-3/alpha-cyclodextrin; 106392-12-5/Poloxamer; 50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Solar disinfection of fungal spores in water aided by low concentrations of hydrogen peroxide.
Next Document: A thiophen-thiooxorhodamine conjugate fluorescent probe for detecting mercury in aqueous media and l...