Document Detail


Predisposing factors to thrombosis in systemic lupus erythematosus: possible relation to endothelial cell damage.
MedLine Citation:
PMID:  458249     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied 28 patients with SLE, five of whom had had thrombotic episodes. Platelet function and coagulation and fibrinolytic studies were performed to determine whether any of these factors may predispose to thrombosis in SLE. An inhibitor of blood coagulation was detected in 12 patients, and von Willebrand's syndrome was observed in two others. The most striking findings which could be correlated with thromboembolic phenomena were the increase in VII R:WF and the absence of plasminogen activator release after venous occlusion. Both proteins are synthesized by the endothelial cell, and the abnormalities observed are possibly related to damage of the vascular endothelium by immune complexes observed in SLE.
Authors:
E Angles-Cano; Y Sultan; J P Clauvel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of laboratory and clinical medicine     Volume:  94     ISSN:  0022-2143     ISO Abbreviation:  J. Lab. Clin. Med.     Publication Date:  1979 Aug 
Date Detail:
Created Date:  1979-09-25     Completed Date:  1979-09-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375375     Medline TA:  J Lab Clin Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  312-23     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Blood Platelets / physiology
Factor VIII
Fibrinolysis
Humans
Lupus Erythematosus, Systemic / complications,  physiopathology*
Thrombosis / etiology,  physiopathology*
Chemical
Reg. No./Substance:
9001-27-8/Factor VIII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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