| Predictors of switching to insulin from non-insulin therapy in patients with type 2 diabetes mellitus. | |
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MedLine Citation:
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PMID: 21051096 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To estimate the switching rate and to identify factors that predict switch from non-insulin to insulin therapy in patients with type 2 diabetes using routinely collected data from a clinical information system at Isfahan Endocrine and Metabolism Research Centre, Iran. METHODS: During the mean (SD) follow-up period of 9.3 (3.4) years, 6896 non-insulin-treated patients with type 2 diabetes at baseline have been examined to determine predictors of switches to insulin therapy. Their treatment at the last clinic visit was compared with the initial visit treatment. The mean (SD) age of participants was 51.2 (10.3) years with a mean (SD) duration of diabetes of 5.8 (5.9) years at initial registration. RESULTS: The switch to insulin from non-insulin therapy was 2.5 (95% confidence interval 2.4, 2.6) (2.2 men and 2.7 women) per 100 patient-years based on 64,540 patient-years of follow-up. Using a Cox's proportional hazards model, younger age at diagnosis, female gender, higher BMI and HbA(1c) were significant predictors of switch to insulin treatment. CONCLUSIONS: These are the first estimate of switch to insulin from non-insulin therapy in Iran. Younger age at diagnosis, female gender, higher BMI and HbA(1c) at registration were identified as predictors of switching to insulin. |
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Authors:
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Mohsen Janghorbani; Mohsen Janghorban; Masoud Amini |
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Publication Detail:
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Type: Journal Article Date: 2010-11-03 |
Journal Detail:
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Title: Diabetes research and clinical practice Volume: 92 ISSN: 1872-8227 ISO Abbreviation: Diabetes Res. Clin. Pract. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-18 Completed Date: 2011-10-04 Revised Date: 2011-10-12 |
Medline Journal Info:
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Nlm Unique ID: 8508335 Medline TA: Diabetes Res Clin Pract Country: Ireland |
Other Details:
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Languages: eng Pagination: 111-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran. janghorbani@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Diabetes Mellitus, Type 2
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diet therapy*,
drug therapy* Female Humans Insulin / therapeutic use* Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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11061-68-0/Insulin |
| Comments/Corrections | |
Erratum In:
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Diabetes Res Clin Pract. 2011 Jul;93(1):131 Note: Janghorban, Mohsen [corrected to Janghorbani, Mohsen] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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