Document Detail


Predictors of sudden cardiac death in hypertrophic cardiomyopathy.
MedLine Citation:
PMID:  9761089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with hypertrophic cardiomyopathy (HC) die suddenly. Proposed risk factors for sudden cardiac death (SCD) in HC are youth, a family history of SCD, syncope, and ventricular tachycardia. Hemodynamic variables have not convincingly proved to be risk factors for SCD. Therefore, this study was designed to examine predictors of SCD in a large number of patients with HC during long-term follow-up periods. The relation of studied variables (clinical, electrocardiographic, echocardiographic, hemodynamic, and exercise test findings) to SCD in 309 patients with HC who were initially diagnosed during 1971 through 1994 (mean follow-up 9.4 years) was examined by multivariate analysis. SCD occurred in 28 patients. Independent predictors of SCD were a smaller difference between peak and rest systolic blood pressure during exercise testing (p=0.006), and higher left ventricular outflow tract pressure gradient at rest (p=0.003). Exercise-related SCD occurred in 8 patients and exercise-unrelated SCD in 20 patients (mean age 28 vs 47 years, p <0.05). Thus, patients of exercise-related SCD were younger and had smaller increases in systolic blood pressure during exercise testing, whereas patients with exercise-unrelated SCD were older and had higher left ventricular outflow tract pressure gradient.
Authors:
S Maki; H Ikeda; A Muro; N Yoshida; A Shibata; Y Koga; T Imaizumi
Related Documents :
11528339 - Atrioventricular plane displacement in female endurance athletes.
3571749 - Effects of diltiazem on left ventricular diastolic behavior in patients with hypertroph...
7380709 - Responses to continuous negative-pressure breathing in man at rest and during exercise.
3872589 - Ventricular arrhythmias induced by dynamic and static exercise in relation to coronary ...
11533149 - Cardiac performance in inbred rat genetic models of low and high running capacity.
7679869 - Reduction of exercise-induced ventricular arrhythmias in mild symptomatic heart failure...
2545659 - Beta-adrenergic receptors are not responsible for exercise stimulation of glucose trans...
1459749 - Physiological changes in male competitive cyclists after two weeks of intensified train...
25303169 - Step aerobic combined with resistance training improves cutaneous microvascular reactiv...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of cardiology     Volume:  82     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-10-20     Completed Date:  1998-10-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  774-8     Citation Subset:  AIM; IM    
Affiliation:
The Department of Internal Medicine III, The Kurume University Medical Center, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Cardiomyopathy, Hypertrophic / complications,  diagnosis,  mortality*
Child
Child, Preschool
Death, Sudden, Cardiac / epidemiology,  etiology*
Echocardiography
Electrocardiography
Exercise Test
Female
Follow-Up Studies
Hemodynamics
Humans
Incidence
Male
Middle Aged
Prognosis
Retrospective Studies
Risk Factors
Survival Rate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Likelihood of underreporting of outlet strut fracture from examination of the Dutch Björk-Shiley CC...
Next Document:  Risk stratification in patients with dilated cardiomyopathy: contribution of Doppler-derived left ve...