Document Detail


Predictors of sudden cardiac death in hypertrophic cardiomyopathy.
MedLine Citation:
PMID:  9761089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with hypertrophic cardiomyopathy (HC) die suddenly. Proposed risk factors for sudden cardiac death (SCD) in HC are youth, a family history of SCD, syncope, and ventricular tachycardia. Hemodynamic variables have not convincingly proved to be risk factors for SCD. Therefore, this study was designed to examine predictors of SCD in a large number of patients with HC during long-term follow-up periods. The relation of studied variables (clinical, electrocardiographic, echocardiographic, hemodynamic, and exercise test findings) to SCD in 309 patients with HC who were initially diagnosed during 1971 through 1994 (mean follow-up 9.4 years) was examined by multivariate analysis. SCD occurred in 28 patients. Independent predictors of SCD were a smaller difference between peak and rest systolic blood pressure during exercise testing (p=0.006), and higher left ventricular outflow tract pressure gradient at rest (p=0.003). Exercise-related SCD occurred in 8 patients and exercise-unrelated SCD in 20 patients (mean age 28 vs 47 years, p <0.05). Thus, patients of exercise-related SCD were younger and had smaller increases in systolic blood pressure during exercise testing, whereas patients with exercise-unrelated SCD were older and had higher left ventricular outflow tract pressure gradient.
Authors:
S Maki; H Ikeda; A Muro; N Yoshida; A Shibata; Y Koga; T Imaizumi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of cardiology     Volume:  82     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-10-20     Completed Date:  1998-10-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  774-8     Citation Subset:  AIM; IM    
Affiliation:
The Department of Internal Medicine III, The Kurume University Medical Center, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Cardiomyopathy, Hypertrophic / complications,  diagnosis,  mortality*
Child
Child, Preschool
Death, Sudden, Cardiac / epidemiology,  etiology*
Echocardiography
Electrocardiography
Exercise Test
Female
Follow-Up Studies
Hemodynamics
Humans
Incidence
Male
Middle Aged
Prognosis
Retrospective Studies
Risk Factors
Survival Rate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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