Document Detail

Predictors of specialized intestinal metaplasia in patients with an incidental irregular Z line.
MedLine Citation:
PMID:  19907339     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Barrett's esophagus is a well-known complication of gastroesophageal reflux disease (GERD) and is associated with dysplasia and esophageal adenocarcinoma. Data on the prevalence of specialized intestinal metaplasia (SIM) in biopsy taken from an incidental irregular Z line are scarce. AIM: To determine the prevalence of SIM in biopsies taken from an incidental irregular Z line in consecutive patients undergoing upper endoscopy. METHODS: During the study period, we identified all adult patients who underwent an upper endoscopy with biopsies from an incidental finding of an irregular Z line. Demographic characteristics, prevalence of endoscopic findings, and major complaints were compared between those with SIM and those without. RESULTS: A total of 166 out of 2000 (8.3%) consecutive patients were identified. Specialized intestinal metaplasia was found in 43.5% of all cases. Male sex and the presence of hiatus hernia were predictors of SIM (P=0.043 and 0.001, respectively), with relative risks of 2.02 (95% confidence interval: 1.01-4.0) and 3.31 (95% confidence interval: 1.66-6.58), respectively. CONCLUSION: In this endoscopic and histological study, SIM was found to be a common finding in patients with irregular Z line. Male sex and the presence of diaphragmatic hernia were significantly associated with the presence of SIM.
Ram Dickman; Zohar Levi; Alex Vilkin; Ibrahim Zvidi; Yaron Niv
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  22     ISSN:  1473-5687     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-11     Completed Date:  2010-03-12     Revised Date:  2010-07-20    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  135-8     Citation Subset:  IM    
Department of Gastroenterology, Rabin Medical Center, Beilinson Hospital, Tel Aviv University, Israel.
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MeSH Terms
Aged, 80 and over
Barrett Esophagus / ethnology,  etiology,  pathology*
Esophagus / pathology*
Gastroesophageal Reflux / complications,  ethnology,  pathology*
Hernia, Hiatal / complications
Israel / epidemiology
Logistic Models
Middle Aged
Retrospective Studies
Risk Assessment
Risk Factors
Sex Factors
Young Adult
Comment In:
Eur J Gastroenterol Hepatol. 2010 Aug;22(8):1022   [PMID:  20631542 ]

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