| Predictors of specialized intestinal metaplasia in patients with an incidental irregular Z line. | |
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MedLine Citation:
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PMID: 19907339 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Barrett's esophagus is a well-known complication of gastroesophageal reflux disease (GERD) and is associated with dysplasia and esophageal adenocarcinoma. Data on the prevalence of specialized intestinal metaplasia (SIM) in biopsy taken from an incidental irregular Z line are scarce. AIM: To determine the prevalence of SIM in biopsies taken from an incidental irregular Z line in consecutive patients undergoing upper endoscopy. METHODS: During the study period, we identified all adult patients who underwent an upper endoscopy with biopsies from an incidental finding of an irregular Z line. Demographic characteristics, prevalence of endoscopic findings, and major complaints were compared between those with SIM and those without. RESULTS: A total of 166 out of 2000 (8.3%) consecutive patients were identified. Specialized intestinal metaplasia was found in 43.5% of all cases. Male sex and the presence of hiatus hernia were predictors of SIM (P=0.043 and 0.001, respectively), with relative risks of 2.02 (95% confidence interval: 1.01-4.0) and 3.31 (95% confidence interval: 1.66-6.58), respectively. CONCLUSION: In this endoscopic and histological study, SIM was found to be a common finding in patients with irregular Z line. Male sex and the presence of diaphragmatic hernia were significantly associated with the presence of SIM. |
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Authors:
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Ram Dickman; Zohar Levi; Alex Vilkin; Ibrahim Zvidi; Yaron Niv |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of gastroenterology & hepatology Volume: 22 ISSN: 1473-5687 ISO Abbreviation: Eur J Gastroenterol Hepatol Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-11 Completed Date: 2010-03-12 Revised Date: 2010-07-20 |
Medline Journal Info:
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Nlm Unique ID: 9000874 Medline TA: Eur J Gastroenterol Hepatol Country: England |
Other Details:
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Languages: eng Pagination: 135-8 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Rabin Medical Center, Beilinson Hospital, Tel Aviv University, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Barrett Esophagus / ethnology, etiology, pathology* Biopsy Esophagoscopy* Esophagus / pathology* Female Gastroesophageal Reflux / complications, ethnology, pathology* Hernia, Hiatal / complications Humans Israel / epidemiology Logistic Models Male Metaplasia Middle Aged Prevalence Retrospective Studies Risk Assessment Risk Factors Sex Factors Young Adult |
| Comments/Corrections | |
Comment In:
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Eur J Gastroenterol Hepatol. 2010 Aug;22(8):1022
[PMID:
20631542
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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