Document Detail

Predictors of serum ferritin and serum soluble transferrin receptor in newborns and their associations with iron status during the first 2 y of life.
MedLine Citation:
PMID:  17616764     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Adequate iron status at birth may prevent iron deficiency in early childhood. OBJECTIVES: We aimed to identify predictors of serum ferritin (SF) and serum soluble transferrin receptor (sTfR) in healthy newborns and to relate these iron indexes to iron status in the first 2 y of life. DESIGN: Using bivariate correlations and linear regression, we related various factors in pregnancy to SF (n=363) and sTfR (n=350) in healthy, term infants. Measurements of cord SF and sTfR were compared with those of SF and sTfR at 6, 12, and 24 mo. All 4 measurements were available for 191 and 169 infants for SF and sTfR, respectively. RESULTS: Geometric mean (and 95% CI) cord SF and sTfR measurements were 159 (148, 171) microg/L and 7.3 (7.0, 7.6) mg/L, respectively. Cord SF correlated with sTfR (rho=-0.21, P<0.001). In regression analysis, cord SF correlated with smoking and the use of iron supplements during pregnancy (partial r=-0.12 and 0.16; P<0.05 for both). Cord sTfR was associated with first trimester BMI, gestational age, and male sex (partial r=0.30, 0.24, and 0.19, respectively; P<0.01 for all). Cord SF correlated with SF at 6, 12, and 24 mo (rho=0.45, 0.31, and 0.16 respectively; P<0.05 for all). At age 6 mo, 16 of 17 infants with SF <15 mug/L were boys. CONCLUSIONS: Cessation of smoking and adequate iron prophylaxis during pregnancy may improve iron status in infancy. Cord SF is a predictor of iron status in the first 2 y of life. Boys are at particular risk of low iron status in early infancy.
Gry Hay; Helga Refsum; Andrew Whitelaw; Elisabeth Lind Melbye; Egil Haug; Berit Borch-Iohnsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  86     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-09     Completed Date:  2007-09-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  64-73     Citation Subset:  AIM; IM    
Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
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MeSH Terms
Ferritins / blood*
Fetal Blood
Infant, Newborn / blood*
Iron / metabolism*
Longitudinal Studies
Pregnancy / metabolism*
Receptors, Transferrin / blood*
Regression Analysis
Sex Factors
Reg. No./Substance:
0/Receptors, Transferrin; 7439-89-6/Iron; 9007-73-2/Ferritins

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