Document Detail

Predictors of right ventricular systolic dysfunction in compensated and decompensated heart failure.
MedLine Citation:
PMID:  22994442     Owner:  NLM     Status:  In-Data-Review    
©2012 Wiley Periodicals Inc. Current understanding of the mechanisms of right ventricular (RV) systolic dysfunction in heart failure (HF) is limited. The authors analyzed a limited access dataset from the Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness (ESCAPE) provided by the National Heart, Lung, and Blood Institute (NHLBI). RV systolic function was measured by echocardiography at baseline and at 3-month follow-up using fractional area change. Univariate and multivariate analysis was performed with linear regression. Of 433 patients enrolled in the ESCAPE trial, 190 had RV systolic function measured at baseline (decompensated HF) and 147 had it measured at 3-month follow-up. On both occasions, parameters of congestion were associated with RV systolic function. Interestingly, lower hematocrit level was also associated with better RV systolic function. In multivariate analysis, only wedge pressure remained a statistically significant predictor of RV dysfunction. In summary, cardiac diastolic pressures and corresponding echocardiographic parameters, as well as hematocrit level, predicted RV systolic function in both compensated and decompensated systolic HF.
Maya Guglin; Cho Mya Win; Nellie Darbinyan; Yougui Wu
Publication Detail:
Type:  Journal Article     Date:  2012-04-04
Journal Detail:
Title:  Congestive heart failure (Greenwich, Conn.)     Volume:  18     ISSN:  1751-7133     ISO Abbreviation:  Congest Heart Fail     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9714174     Medline TA:  Congest Heart Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  278-83     Citation Subset:  IM    
Copyright Information:
© 2012 Wiley Periodicals, Inc.
From the Department of Cardiology, University of South Florida, Tampa, FLCollege of Public Health, University of South Florida, Tampa, FL.
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