Document Detail


Predictors of renal involvement in patients with systemic lupus erythematosus.
MedLine Citation:
PMID:  17891918     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
From a cohort of 109 patients (105 females and 4 males) treated for systemic lupus erythematosus (SLE), 20 patients (18.3%) developed new episodes of lupus nephritis and 89 patients (81.7%) remained free of renal involvement during the follow-up period. The mean duration of follow up was 39.1 +/- 54.4 months. Clinical characteristics associated with developing lupus nephritis were a high systolic blood pressure (> or = 130 mmHg), photosensitivity, cutaneous vasculitis and gastrointestinal (GI) symptoms. Laboratory abnormalities associated with the development of lupus nephritis were hemoglobin < 10 mg/dl, hematocrit < 30%, blood urea nitrogen > 12 mg/dl, serum creatinine > 1.3 mg/dl, ESR > 60, the third component of complement (C3) level < 0.45 and positive antidsDNA antibody. After a multivariable analysis, only high systolic blood pressure, cutaneous vasculitis, hemoglobin < 10 mg/dl and serum creatinine > 1.3 mg/dl remained as statistically significant risk factors for developing lupus nephritis.
Authors:
Bancha Satirapoj; Jeerapat Wongchinsri; Nantana Youngprang; Boonraksa Laonapaporn; Thongdee Chitrada; Sumonkarn Lapkittichareonchai; Jayanton Patumanon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Asian Pacific journal of allergy and immunology / launched by the Allergy and Immunology Society of Thailand     Volume:  25     ISSN:  0125-877X     ISO Abbreviation:  Asian Pac. J. Allergy Immunol.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-09-25     Completed Date:  2007-11-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8402034     Medline TA:  Asian Pac J Allergy Immunol     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  17-25     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Nopparat Rajathanee Hospital, Thailand. satirapoj@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies, Antinuclear / blood
Cohort Studies
Female
Humans
Hypertension / physiopathology
Kidney / physiopathology
Lupus Erythematosus, Systemic / complications,  immunology,  physiopathology*
Lupus Nephritis / etiology*,  immunology,  physiopathology
Male
Middle Aged
Risk Factors
Chemical
Reg. No./Substance:
0/Antibodies, Antinuclear

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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