Document Detail


Predictors of radiographic joint damage in patients with early rheumatoid arthritis.
MedLine Citation:
PMID:  11557647     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine factors at diagnosis, associated with radiographic damage at diagnosis and after one year, in patients with early rheumatoid arthritis (RA). METHODS: New patients with early RA were followed up for one year. Possible prognostic factors were duration of complaints, morning stiffness, disease activity score (DAS28), functional status (Health Assessment Questionnaire (HAQ) score), rheumatoid factor (IgM RF), and C reactive protein (CRP). Outcome was defined as radiographic damage of the hands and feet (Sharp/van der Heijde score). For the statistical analysis, one way analysis of variance and a forward stepwise logistic regression model was used. RESULTS: 130 patients with RA (68% female; median age 64 years, range 21-86) were included. Despite the fact that the median duration of complaints was short (15 weeks, range 2-106) the radiographic damage at diagnosis was significantly correlated with the duration of complaints (p<0.05). Patients with a duration of complaints of >34 weeks had significantly more radiographic joint damage at diagnosis than patients with a shorter duration of complaints. Radiographic progression at one year was correlated with high radiographic joint damage, high CRP level, and a positive IgM RF at entry. CONCLUSIONS: In early RA, the number of radiographic lesions was correlated with a longer duration of complaints at the first visit. Progression of these lesions was predicted by a high baseline joint damage, high CRP level, and a positive IgM RF. Further reduction of the delay in referral and early treatment may further decrease joint damage in patients with recent onset polyarthritis.
Authors:
L M Jansen; I E van der Horst-Bruinsma; D van Schaardenburg; P D Bezemer; B A Dijkmans
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  60     ISSN:  0003-4967     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-09-14     Completed Date:  2001-10-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  924-7     Citation Subset:  IM    
Affiliation:
Jan van Breemen Instituut, Amsterdam, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Activities of Daily Living
Adult
Aged
Aged, 80 and over
Analysis of Variance
Antirheumatic Agents / therapeutic use
Arthritis, Rheumatoid / blood,  drug therapy,  radiography*
Blood Sedimentation
C-Reactive Protein / analysis
Female
Humans
Logistic Models
Male
Middle Aged
Predictive Value of Tests
Prognosis
Prospective Studies
Rheumatoid Factor / blood
Time Factors
Chemical
Reg. No./Substance:
0/Antirheumatic Agents; 9007-41-4/C-Reactive Protein; 9009-79-4/Rheumatoid Factor
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