| Predictors of quality of life after resective extratemporal epilepsy surgery in adults in long-term follow-up. | |
| | |
MedLine Citation:
|
PMID: 19428270 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To present long-term outcome and predictors of the health related quality of life (HRQOL) in a large group of patients operated for refractory extratemporal epilepsy. METHODS: A German QOLIE-31 questionnaire and additional questions has been mailed for all adult patients operated for extratemporal epilepsy in the Bethel Epilepsy Centre, between 1992 and 2003, 87 patients were eligible for this study. RESULTS: Seizure freedom, intake of antiepileptic drugs (AEDs), presence of AEDs side effect medical comorbidities and driving a car were significantly correlated to HRQOL in all subscales of QOLIE-31. Gender, age at epilepsy onset, the presence of a partner, psychiatric disease, the presence of auras and tumour pathology have a correlation to QOL in some subscales. Stepwise regression for all patients revealed that seizure freedom and medical comorbidities were highly predictive for most of the subscales of QOLIE-31. Intake of anti-epileptic drugs and AED side effects had a modest effect on QOL. The need for psychiatric treatment predicted poor cognitive function scores. Epilepsy onset at an older age predicted a minimal increase in the overall health scores. An aura at the last follow-up predicted poor medication scores. Regarding the importance of the predictors, seizure freedom and medical comorbidities were the most important predictors of QOL after surgery. AED intake and side effects had an intermediate effect on QOL; however, the gender of the patient and age at epilepsy onset had a minimal effect on QOL. CONCLUSIONS: HRQOL after extratemporal epilepsy surgery has multiple determinants. Medical comorbidities should be considered a negative risk factor for QOL during preoperative and postoperative evaluation process. |
| | |
Authors:
|
Alaa Eldin Elsharkawy; Theodor May; Rupprecht Thorbecke; Alois Ebner |
Publication Detail:
|
Type: Clinical Trial; Journal Article Date: 2009-05-09 |
Journal Detail:
|
Title: Seizure : the journal of the British Epilepsy Association Volume: 18 ISSN: 1532-2688 ISO Abbreviation: Seizure Publication Date: 2009 Sep |
Date Detail:
|
Created Date: 2009-08-11 Completed Date: 2009-11-02 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9306979 Medline TA: Seizure Country: England |
Other Details:
|
Languages: eng Pagination: 498-503 Citation Subset: IM |
Affiliation:
|
Neurosurgical Department, Bethel Epilepsy Centre, Germany. alaa.elsharkawy@mara.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Analysis of Variance Anticonvulsants / therapeutic use* Epilepsy / psychology*, therapy* Female Health Status* Humans Longitudinal Studies Male Neurosurgical Procedures / statistics & numerical data* Quality of Life / psychology* Questionnaires Time Factors Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Anticonvulsants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cerebrospinal fluid tau as a marker of neuronal damage after epileptic seizure.
Next Document: Diagnostic usefulness and duration of the inpatient long-term video-EEG monitoring: findings in pati...