Document Detail


Predictors of prognosis in patients with olfactory disturbance.
MedLine Citation:
PMID:  18058814     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Although olfaction is often compromised by such factors as head trauma, viruses, and toxic agents, the olfactory epithelium and sectors of the olfactory bulb have the potential for regeneration. This study assessed the degree to which olfactory function changes over time in patients presenting to a university-based smell and taste center with complaints of olfactory dysfunction and the influences of etiology (eg, head trauma, upper respiratory infection), sex, age, smoking behavior, degree of initial dysfunction, and other factors on such change. METHODS: Well-validated odor identification tests were administered to 542 patients on 2 occasions separated from one another by 3 months to 24 years. Multivariable regression and chi2 analyses assessed the influences of the variables on the longitudinal changes in olfactory test scores. RESULTS: On average, smell test scores improved modestly over time. Patient age, severity of initial olfactory loss, and the duration of dysfunction at first testing were significant predictors of the amount of the change. Etiology, sex, time between the two test administrations, and initial smoking behavior were not significant predictors. The percentage of anosmic and microsmic patients exhibiting statistically significant change in function was 56.72 and 42.86%, respectively. However, only 11.31% of anosmic and 23.31% of microsmic patients regained normal age-related function over time. INTERPRETATION: Some recovery can be expected in a significant number of patients who experience smell loss. The amount of recovery depends on the degree of initial loss, age, and the duration of loss. Etiology, per se, is not a significant determinant of prognosis, in contrast with what is commonly believed.
Authors:
Brian London; Behnam Nabet; Andrew R Fisher; Brigitte White; Mary D Sammel; Richard L Doty
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Annals of neurology     Volume:  63     ISSN:  1531-8249     ISO Abbreviation:  Ann. Neurol.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-03-04     Completed Date:  2008-04-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  159-66     Citation Subset:  IM    
Affiliation:
Department of Otorhinolaryngology: Head and Neck Surgery, Smell and Taste Center, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Cohort Studies
Female
Humans
Male
Middle Aged
Nerve Regeneration / physiology*
Neurologic Examination
Neurons / physiology
Olfaction Disorders / diagnosis*,  etiology,  physiopathology
Olfactory Mucosa / physiology
Olfactory Pathways / physiopathology*
Predictive Value of Tests
Prognosis
Recovery of Function / physiology*
Severity of Illness Index
Sex Factors
Smell / physiology
Stem Cells / physiology
Grant Support
ID/Acronym/Agency:
P01 DC00161/DC/NIDCD NIH HHS; R01 AG17496/AG/NIA NIH HHS; R01 DC 02974/DC/NIDCD NIH HHS; R01 DC04278/DC/NIDCD NIH HHS
Comments/Corrections
Comment In:
Ann Neurol. 2008 Feb;63(2):132-4   [PMID:  18306414 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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