Document Detail


Predictors of pregnancy and changes in pregnancy incidence among HIV-positive women accessing HIV clinical care.
MedLine Citation:
PMID:  22713479     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To describe predictors of pregnancy and changes in pregnancy incidence among HIV-positive women accessing HIV clinical care.
METHODS: Data were obtained through the linkage of two separate studies: the UK Collaborative HIV Cohort study (UK CHIC), a cohort of adults attending 13 large HIV clinics; and the National Study of HIV in Pregnancy and Childhood (NSHPC), a national surveillance study of HIV-positive pregnant women. Pregnancy incidence was measured using the proportion of women in UK CHIC with a pregnancy reported to NSHPC. Generalized estimating equations were used to identify predictors of pregnancy and assess changes in pregnancy incidence in 2000-2009.
RESULTS: The number of women accessing care at UK CHIC sites increased as did the number of pregnancies. Older women were less likely to have a pregnancy [adjusted relative rate (aRR) 0.44 per 10 year increment in age, [95% confidence interval (CI) (0.41-0.46)], P < 0.001] as were women with CD4 cell count less than 200 cells/μl compared with CD4 cell count 200-350 cells/μl [aRR 0.65 (0.55-0.77), P < 0.001] and women of white ethnicity compared with women of black African ethnicity [aRR 0.67 (0.57-0.80), P < 0.001]. The likelihood that women had a pregnancy increased over the study period [aRR 1.05 (1.03-1.07), P < 0.001). The rate of change did not significantly differ according to age group, antiretroviral therapy use, CD4 group or ethnicity.
CONCLUSION: The pregnancy rate among women accessing HIV clinical care increased in 2000-2009. HIV-positive women with, or planning, a pregnancy require a high level of care and this is likely to continue and increase as more women of older age have pregnancies.
Authors:
Susie E Huntington; Claire Thorne; Loveleen K Bansi; Jane Anderson; Marie-Louise Newell; Graham P Taylor; Deenan Pillay; Teresa Hill; Pat A Tookey; Caroline A Sabin;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  AIDS (London, England)     Volume:  27     ISSN:  1473-5571     ISO Abbreviation:  AIDS     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-12     Completed Date:  2013-06-17     Revised Date:  2014-06-17    
Medline Journal Info:
Nlm Unique ID:  8710219     Medline TA:  AIDS     Country:  England    
Other Details:
Languages:  eng     Pagination:  95-103     Citation Subset:  IM; X    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
CD4 Lymphocyte Count
Cohort Studies
Female
Great Britain / epidemiology
HIV Seropositivity / epidemiology*
Humans
Incidence
Infectious Disease Transmission, Vertical / prevention & control,  statistics & numerical data*
Middle Aged
Patient Acceptance of Health Care / statistics & numerical data*
Predictive Value of Tests
Pregnancy
Pregnancy Complications, Infectious / epidemiology*,  prevention & control
Prenatal Care / utilization*
Reproductive Behavior / statistics & numerical data*
Sentinel Surveillance
Time Factors
Grant Support
ID/Acronym/Agency:
081082//Wellcome Trust; 097410//Wellcome Trust; G00001999//Medical Research Council; G0600337//Medical Research Council; MR/K006584/1//Medical Research Council; //Wellcome Trust
Investigator
Investigator/Affiliation:
D Asboe / ; Jonathan Ainsworth / ; Abdel Babiker / ; David Chadwick / ; Valerie Delpech / ; David Dunn / ; Martin Fisher / ; Brian Gazzard / ; Richard Gilson / ; Mark Gompels / ; Phillip Hay / ; Margaret Johnson / ; Stephen Kegg / ; Clifford Leen / ; Mark Nelson / ; Chloe Orkin / ; Adrian Palfreeman / ; Andrew Phillips / ; Frank Post / ; Memory Sachikonye / ; Achim Schwenk / ; John Walsh / ; Sophie Josie / ; Andrew Phillips / ; Alicia Thornton / ; David Dunn / ; Adam Glabay / ; C Orkin / ; N Garrett / ; J Lynch / ; J Hand / ; C de Souza / ; M Fisher / ; N Perry / ; S Tilbury / ; B Gazzard / ; M Nelson / ; M Waxman / ; S Mandalia / ; V Delpech / ; S Munshi / ; H Korat / ; J Welch / ; M Poulton / ; C MacDonald / ; Z Gleisner / ; L Campbell / ; R Gilson / ; N Brima / ; I Williams / ; A Schwenk / ; J Ainsworth / ; C Wood / ; S Miller / ; M Johnson / ; M Youle / ; F Lampe / ; C Smith / ; H Grabowska / ; C Chaloner / ; D Puradiredja / ; J Walsh / ; J Weber / ; F Ramzan / ; N Mackie / ; A Winston / ; C Leen / ; A Wilson / ; M Gompels / ; S Allan / ; A Palfreeman / ; A Moore / ; D Chadwick / ; K Wakeman /
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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