Document Detail

Predictors of poor outcome in neonates with bacterial sepsis admitted to the University Hospital of the West Indies.
MedLine Citation:
PMID:  16921699     Owner:  NLM     Status:  MEDLINE    
To determine factors that affect outcome in neonates with culture-proven sepsis, the charts of all neonates with culture-proven sepsis admitted to the University Hospital of the West Indies between January 1995 and December 2000 were reviewed retrospectively. Neonates who survived without developing any complications (favourable outcome group) were compared with those who died and/or developed severe complications during the course of treatment (poor outcome group). Chi-square tests were done to determine factors associated with poor outcome; univariate and multivariate logistic regression analyses were also performed. One hundred and thirty-five neonates had culture-proven sepsis, of which 89 (66%) were term infants and 46 (34%) were preterm. Male to female ratio was 1.6:1. One hundred and twenty-six (93%) survived and 9 (7%) died. Case fatality rates were higher for premature infants (15%) than for term infants (2%). Twenty-four (18%) of the neonates with culture proven sepsis had a poor outcome. Gram negative organisms accounted for 19 (70%) of the cases with poor outcome. Prematurity (p < 0.001), very low birthweight (p < 0.001) and female gender (p < 0.05) were factors associated with poor outcome. Strategies aimed at decreasing morbidity and mortality in neonates with sepsis must include measures that will decrease the incidence of prematurity and low birthweight.
H Trotman; Y Bell; M Thame; A M Nicholson; M Barton
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The West Indian medical journal     Volume:  55     ISSN:  0043-3144     ISO Abbreviation:  West Indian Med J     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-08-22     Completed Date:  2006-10-06     Revised Date:  2008-03-10    
Medline Journal Info:
Nlm Unique ID:  0417410     Medline TA:  West Indian Med J     Country:  Jamaica    
Other Details:
Languages:  eng     Pagination:  80-4     Citation Subset:  IM    
Department of Obstetrics Gynaecology, The University of the West Indies, Kingston 7, Jamaica.
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MeSH Terms
Analysis of Variance
Bacteremia / epidemiology,  therapy*
Birth Weight
Gestational Age
Gram-Negative Bacterial Infections / epidemiology,  microbiology,  therapy
Gram-Positive Bacterial Infections / epidemiology,  microbiology,  therapy
Hospitals, University*
Infant, Newborn
Patient Admission*
Predictive Value of Tests
Retrospective Studies
Risk Factors
Treatment Outcome
West Indies / epidemiology

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