Document Detail

Predictors of outcome in prophylactic lithium treatment: a 2-year prospective study.
MedLine Citation:
PMID:  2140378     Owner:  NLM     Status:  MEDLINE    
The purpose of this study of 133 affective disorder patients consecutively referred to start prophylactic lithium treatment was to identify informative predictors of outcome. Non-adherence to treatment was mainly predicted by substance abuse and many earlier admissions. Non-response among the 78 patients adhering to lithium treatment was mainly predicted by female sex, young age and previously chronic course. The overall response rate was rather poor and an excess mortality rate was found. It is suggested that patients with substance abuse should not be offered prophylactic lithium treatment unless intensive control and support is practicable, and patients with a chronic course need a more effective treatment than lithium can offer.
J Aagaard; P Vestergaard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of affective disorders     Volume:  18     ISSN:  0165-0327     ISO Abbreviation:  J Affect Disord     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-06-27     Completed Date:  1990-06-27     Revised Date:  2009-09-28    
Medline Journal Info:
Nlm Unique ID:  7906073     Medline TA:  J Affect Disord     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  259-66     Citation Subset:  IM    
Clinical Department A, Institute of Psychiatric Demography, Aarhus Psychiatric Hospital, Risskov, Denmark.
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MeSH Terms
Bipolar Disorder / prevention & control*,  psychology
Follow-Up Studies
Lithium / administration & dosage*
Middle Aged
Patient Admission
Patient Compliance*
Risk Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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