| Predictors of outcome in patients with cystic fibrosis requiring endotracheal intubation. | |
| | |
MedLine Citation:
|
PMID: 23323684 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND AND OBJECTIVE: Acute severe clinical deterioration of patients with cystic fibrosis (CF) may mandate endotracheal intubation. We evaluated the benefits of intubation by examining which pre-admission parameters were associated with ICU outcome; and assessing the potential benefits of intubation for survivors in terms of time from ICU discharge to death. METHODS: A retrospective analysis of data from a single centre was undertaken. RESULTS: Thirty patients required intubation on 34 occasions (8 per 1000 admissions). Eleven patients died in ICU, and 7 after ICU but not hospital discharge. 59% of 22 patients intubated for pneumothorax and/or haemoptysis survived to hospital discharge. Of the twelve intubated for infective exacerbations, 33% survived to hospital discharge. Those who died after hospital discharge survived 447 days. There were no significant differences for survivors in reasons for intubation; colonising organism; frequency of infective exacerbations, severity of illness or pulmonary physiology. Osteoporosis and a greater fall in BMI over the 24 months prior were more frequent in non-survivors. CONCLUSIONS: Patients with CF developing haemoptysis and/or pneumothorax should be admitted to ICU and intubated promptly should this be required. Chronic disease markers may be more relevant prognostically than rates of hospitalisation or FEV1 decline which should not be bars to invasive ventilation. |
| | |
Authors:
|
Andrew Jones; Diana Bilton; Timothy W Evans; Simon J Finney |
Related Documents
:
|
23271794 - Concomitant use of antiplatelet therapy with dabigatran or warfarin in the randomized e... 23551634 - Visceral varicella zoster virus infection after allogeneic stem cell transplantation. 23037464 - A case series of bacillus cereus septicemia in patients with hematological disease. 23622424 - Patients readmitted to the intensive care unit: can they be prevented? 22247624 - Communication gaps between physicians and patients with postherpetic neuralgia: results... 16278344 - Videofluoroscopy and swallowing studies for neurologic disease: a primer. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-17 |
Journal Detail:
|
Title: Respirology (Carlton, Vic.) Volume: - ISSN: 1440-1843 ISO Abbreviation: Respirology Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9616368 Medline TA: Respirology Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2013 The Authors. Respirology © 2013 Asian Pacific Society of Respirology. |
Affiliation:
|
Department of Cystic fibrosis, Royal Brompton Hospital, Sydney Street, London, SW3 6NP, United Kingdom; NIHR Biomedical Research Unit into Advanced Lung Disease, Royal Brompton Hospital, Sydney Street, London, SW3 6NP, United Kingdom. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Touch, the essence of caring for people with end-stage dementia: A mental health perspective in Nama...
Next Document: Expedient Synthesis of Highly Potent Antagonists of Inhibitor of Apoptosis Proteins (IAPs) with Uniq...