| Predictors of outcome in fungal keratitis. | |
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MedLine Citation:
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PMID: 22744392 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To analyse predictors of clinical outcome in fungal keratitis. METHODS: Data was collected during a prospective, randomized, controlled, double-masked clinical trial of treatment for fungal keratitis. Clinical features at presentation and demographics were collected at the enrollment visit for all patients. Pre-specified clinical outcomes included 3-month visual acuity and infiltrate/scar size, time to re-epithelialization, and corneal perforation. A separate multivariable model with each outcome as the dependent variable included all predictor variables. RESULTS: Predictors for worse 3-month visual acuity include older age (P=0.024), worse presentation visual acuity (P<0.001), larger infiltrate size at presentation (P<0.001), and pigmented ulcer (P=0.030). Larger infiltrate size at presentation was a significant predictor of worse 3-month infiltrate/scar size (P<0.001). Larger epithelial defect size was a significant predictor of perforation (P=0.0013). Predictors of longer time to re-epithelialization include infiltrate size at presentation (P<0.001) and older age (P=0.025). CONCLUSION: Ulcer severity at presentation is highly predictive of worse outcomes. Presentation of clinical characteristics such as baseline acuity and infiltrate scar can provide important information to clinicians about prognosis, and may help guide management and treatment decisions. Prevention of corneal ulcer remains important, as it is difficult to change the course of the ulcer once it has begun. |
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Authors:
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N Venkatesh Prajna; T Krishnan; J Mascarenhas; M Srinivasan; C E Oldenburg; C M Toutain-Kidd; A Sy; S D McLeod; M E Zegans; N R Acharya; T M Lietman; T C Porco |
Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2012-06-29 |
Journal Detail:
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Title: Eye (London, England) Volume: 26 ISSN: 1476-5454 ISO Abbreviation: Eye (Lond) Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-09-17 Completed Date: 2013-01-17 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 8703986 Medline TA: Eye (Lond) Country: England |
Other Details:
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Languages: eng Pagination: 1226-31 Citation Subset: IM |
Affiliation:
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Aravind Eye Care System, Madurai, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Antifungal Agents / therapeutic use Corneal Perforation / diagnosis Corneal Ulcer / diagnosis*, drug therapy, microbiology Debridement Double-Blind Method Eye Infections, Fungal / diagnosis*, drug therapy, microbiology Female Humans Male Natamycin / therapeutic use Ophthalmic Solutions Outcome and Process Assessment (Health Care) Prognosis Prospective Studies Pyrimidines / therapeutic use Re-Epithelialization Risk Factors Time Factors Triazoles / therapeutic use Visual Acuity / physiology |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 0/Ophthalmic Solutions; 0/Pyrimidines; 0/Triazoles; 0/voriconazole; 7681-93-8/Natamycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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