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Predictors of outcome after radical cystectomy for bladder cancer in saudi patients; single institution experience.
MedLine Citation:
PMID:  15959546     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
AIM OF THE STUDY: To evaluate different prognostic factors that may affect disease-specific survival in patients with bladder cancer following radical cystectomy. METHODS: Between July 1975 and December 2000, 229 patients underwent radical cystectomy and urinary diversion for bladder cancer in King Faisal Specialist Hospital and Research Center (KFSH & RC), Riyadh, Saudi Arabia. 175 patients had available records for review. Retrospective chart review was done. Demographic, clinical and pathological variables which may affect disease specific survival in bladder cancer patients were pooled. Univariate and multivariate analyses were done with disease specific survival as an end point. RESULTS: Our patients were 140 males (80%) and 35 females (20%). Their mean age was 54 years (range: 21-90 years). The median follow-up period was 1.5 years (range: one month-19 years). Five-year disease specific survival was 44%. On univariate analysis, patients' age, lymph node status, pathological staging and presence of hydronephrosis were significant predictors of disease specific survival. However, only lymph node status (p<0.0001), pathological staging (p=0.0411) & presence of hydronephrosis (p=0.0264) were significant predictors of disease specific survival in multivariate analysis. CONCLUSION: Pathological stage, lymph node status and upper obstructive uropathy are significant prognostic factors in bladder cancer patients after radical cystectomy. These factors may help to define bladder cancer patient groups who require further therapy or enrollment in controlled trials to investigate additional therapy.
Authors:
Alaa A Mokhtar; Medhat M El-Sebaie; Naser Elkum
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Egyptian National Cancer Institute     Volume:  16     ISSN:  1110-0362     ISO Abbreviation:  J Egypt Natl Canc Inst     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2005-06-16     Completed Date:  2005-10-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9424566     Medline TA:  J Egypt Natl Canc Inst     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  137-44     Citation Subset:  -    
Affiliation:
The Department of Urology, King Faisal Specialist Hospital and Research Centre, Riyadh, KSA. mokhtaralaa@hotmail.com
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