Document Detail

Predictors of non-calcified plaques in the coronary arteries of 242 subjects using multislice computed tomography and logistic regression models.
MedLine Citation:
PMID:  16859769     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We detected non-calcified plaques (NCPs) in the coronary arteries using multislice computed tomography (MSCT) in order to determine the predictors of NCPs using logistic regression models. METHODS: Two hundred and forty-two consecutive subjects (141 males; overall age range, 17-91 years old) underwent enhanced electrocardiogram-gated MSCT to detect NCPs. Logistic models for predicting NCPs were developed which incorporated age, sex, coronary calcified-plaque (CP), and the following coronary risk factors (RFs): hypertension (HT), diabetes mellitus (DM), hyperlipidemia (HL), a smoking habit, and obesity. RESULTS: NCPs were detected in 76 subjects (59 males, 35-82 years old [median=67]) whose average number of coronary RFs was 2.6, 75% of whom presented with HT, 30% with DM, 51% with HL, 64% were present or past cigarette smokers, and 32% were obese. In the 76 subjects with NCPs, the incidence of male sex, presence of HT, a smoking habit, CP and the number of coronary RFs were significantly higher than in the 166 subjects without NCP. Of the 101 female subjects, 17 showed NCPs and in every case the subject was more than 50 years old. In a logistic regression model, male sex, HT and smoking habit (relative risks 2.7, 2.0, and 2.7 [95% confidence interval=1.3-5.6, 1.0-4.0, and 1.5-4.9, respectively]) were associated with increased incidence of NCPs. CONCLUSIONS: The incidence of NCPs was significantly increased in the presence of HT and a smoking habit, suggesting that lesions may be caused by HT or smoking-induced vessel injury even in the young male.
Nobusada Funabashi; Miki Asano; Issei Komuro
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-07-21
Journal Detail:
Title:  International journal of cardiology     Volume:  117     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-27     Completed Date:  2007-05-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  191-7     Citation Subset:  IM    
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba City, Chiba, 260-8670, Japan.
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MeSH Terms
Abstracting and Indexing as Topic
Aged, 80 and over
Calcinosis / epidemiology,  radiography
Coronary Artery Disease / epidemiology*,  radiography*
Logistic Models
Middle Aged
Predictive Value of Tests
Risk Factors
Tomography, X-Ray Computed*

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