Document Detail

Predictors of new-onset diabetes mellitus in hypertensive patients: the VALUE trial.
MedLine Citation:
PMID:  18509347     Owner:  NLM     Status:  MEDLINE    
Diabetes mellitus often develops in patients with hypertension. We investigated predictors of diabetes mellitus development in hypertensives at risk of developing the disease in the VALUE trial population. Among the 9995 non-diabetic hypertensive patients at baseline, 1298 patients developed diabetes mellitus during the average follow-up of 4.2 years. New-onset diabetes mellitus was defined from adverse event reports, information about new antidiabetic medication and/or a fasting glucose >or=7.0 mmol l(-1) at the end of trial. Twenty-five potential baseline predictors of new-onset diabetes mellitus were analysed by univariate logistic regression and 14 of 25 predictors were found to be statistically significant with a P-value <0.05. The predictors were in order of decreasing significance; glucose, body mass index (BMI), age, uric acid, non-Caucasian race, haemoglobin, heart rate, randomized study treatment, history of coronary heart disease (CHD), gender, total cholesterol, proteinuria, potassium and creatinine. Multivariate stepwise logistic regression analyses were used and potential baseline predictors of new-onset diabetes mellitus were considered significant by four different models (P-value <0.001). The final multivariate model selected included all patients, but not treatment group as a potential predictor, and the six significant predictors identified from this model were glucose, BMI, non-Caucasian race, age, heart rate and history of CHD. In conclusion, glucose and BMI were the most important predictors of new-onset diabetes mellitus in hypertensive patients at high cardiovascular risk, and easily accessible clinical characteristics strongly predict patients at risk of developing diabetes mellitus.
T A Aksnes; S E Kjeldsen; M Rostrup; O Störset; T A Hua; S Julius
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-05-29
Journal Detail:
Title:  Journal of human hypertension     Volume:  22     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-17     Completed Date:  2008-12-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  520-7     Citation Subset:  IM    
Department of Cardiology, Ullevaal University Hospital, Oslo, Norway.
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MeSH Terms
Amlodipine / therapeutic use*
Angiotensin II Type 1 Receptor Blockers
Antihypertensive Agents / therapeutic use
Blood Glucose / metabolism
Blood Pressure / physiology
Body Weight
Calcium Channel Blockers / therapeutic use
Diabetes Mellitus / blood,  epidemiology,  etiology*
Double-Blind Method
Drug Therapy, Combination
Follow-Up Studies
Hypertension / complications,  drug therapy*,  physiopathology
Middle Aged
Prospective Studies
Risk Factors
Tetrazoles / therapeutic use*
Time Factors
Valine / analogs & derivatives*,  therapeutic use
Reg. No./Substance:
0/Angiotensin II Type 1 Receptor Blockers; 0/Antihypertensive Agents; 0/Blood Glucose; 0/Calcium Channel Blockers; 0/Tetrazoles; 137862-53-4/valsartan; 7004-03-7/Valine; 88150-42-9/Amlodipine
Comment In:
J Hum Hypertens. 2008 Aug;22(8):517-9   [PMID:  18496556 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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