Document Detail

Predictors of mortality, morbidity, and disability in a cohort of infants < or = 28 weeks' gestation.
MedLine Citation:
PMID:  8258204     Owner:  NLM     Status:  MEDLINE    
This study attempted to identify predictors for mortality, morbidity, disability, and educational handicap at age 4 years in a cohort of 194 infants born at 23 to 28 weeks' gestation at one regionalized tertiary center from 1983 to 1986. Forty-one infants died (21%); standardized neurodevelopmental and functional assessments were conducted on 149 of 153 (97%) survivors at a mean age of 52 months. Five significant predictors of death were identified with logistic regression analysis: gestational age 23 to 26 weeks, intraventricular hemorrhage grades 3 or 4, male gender, five-minute Apgar < or = 3, and absence of prophylactic calf lung surfactant extract. Significant predictors of neurodevelopmental morbidity included sepsis, male gender, and nonwhite race. Significant predictors of disability at age four included neurodevelopmental impairment and severe retinopathy of prematurity. Low socioeconomic status, nonwhite race and male gender were predictive of educational handicap. These findings suggest that outcomes may have distinct pathophysiologies. The role of biomedical events appears strongest for death.
M E Msall; G M Buck; B T Rogers; L C Duffy; S R Mallen; N L Catanzaro
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical pediatrics     Volume:  32     ISSN:  0009-9228     ISO Abbreviation:  Clin Pediatr (Phila)     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1994-01-19     Completed Date:  1994-01-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372606     Medline TA:  Clin Pediatr (Phila)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  521-7     Citation Subset:  AIM; IM    
Department of Pediatrics, School of Medicine and Biomedical Sciences, SUNY at Buffalo.
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MeSH Terms
Child, Preschool
Cohort Studies
Disabled Persons*
Follow-Up Studies
Gestational Age*
Infant, Newborn
Regression Analysis
Sex Factors

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