Document Detail


Predictors of mortality among HIV-infected patients initiating anti retroviral therapy at a tertiary care hospital in eastern India.
MedLine Citation:
PMID:  23199719     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess early mortality and identify its predictors among the ART naive HIV-infected patients initiating anti retroviral therapy (ART) available free of cost at the ART Centres.
METHODS: A retrospective cohort analysis of routinely collected programme data was done for assessing mortality of all ART naive adult patients who received first-line ART at a government tertiary care hospital in eastern India during 1st March 2009 and 28th February 2010. Bivariate and multiple regression analyses of the baseline demographic, clinical and laboratory records using SPSS 15.0 were done to identify independent predictors of mortality.
RESULTS: The mortality rate at one year was estimated to be 7.66 (95%CI 5.84-9.83) deaths/100 patient-years and more than 50% of the deaths occurred during first three months of ART initiation with a median time interval of 73 days. Tuberculosis was the major cause of death. ART naive patients with baseline serum albumin <3.5 mg/dL were eight (OR 7.9; 95%CI: 3.8-16.5) at risk of death than those with higher serum albumin levels and patients with CD4 count <100 cells/μ L were two times (OR 2.2; 95%CI1.1-4.4) at risk of death compared to higher CD4 counts.
CONCLUSIONS: Risk of mortality is increased when ART is initiated at advanced stages of immunosuppression denoted by low serum albumin levels and CD4 cell counts. This highlights the importance of early detection of HIV infection, early management of opportunistic infections including tuberculosis and timely initiation of the antiretroviral drugs in the resource-limited countries, now available free in the Indian national ART programme.
Authors:
Ananya Bhowmik; Subhasis Bhandari; Rajyasree De; Subhasish Kamal Guha
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Asian Pacific journal of tropical medicine     Volume:  5     ISSN:  1995-7645     ISO Abbreviation:  Asian Pac J Trop Med     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-08-14     Revised Date:  2013-09-18    
Medline Journal Info:
Nlm Unique ID:  101533720     Medline TA:  Asian Pac J Trop Med     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  986-90     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Hainan Medical College. Published by Elsevier B.V. All rights reserved.
Affiliation:
Centre of Excellence in HIV, School of Tropical Medicine, 108, Chittaranjan Avenue, Kolkata 700073, West Bengal, India.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Anti-Retroviral Agents / therapeutic use*
Cohort Studies
Female
HIV Infections / drug therapy*,  epidemiology,  microbiology,  mortality*
Humans
India / epidemiology
Male
Middle Aged
Regression Analysis
Retrospective Studies
Risk Factors
Tertiary Healthcare / statistics & numerical data*
Tuberculosis / epidemiology,  virology
Chemical
Reg. No./Substance:
0/Anti-Retroviral Agents

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