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Predictors of long-term remission in patients with Graves' disease: a single center experience.
MedLine Citation:
PMID:  23397523     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Antithyroid drugs (ATDs) remain the first-line therapy in patients with Graves' disease (GD), despite a high relapse rate. The purpose of this study was to identify the predictors of remission in patients with GD treated with ATDs-retrospective study at an endocrine referral service in Northern Greece. Two-hundred and eleven patients met the study's criteria. Females (p = 0.049), non-smokers (p = 0.017), patients without ophthalmopathy (p = 0.033), and those developing pharmaceutical hypothyroidism (p = 0.018) experienced longer duration of remission. Duration of remission was positively associated with therapy duration (r (s) = 0.151, p = 0.030), maximum TSH levels during (r (s) = 0.241, p = 0.001), at the end (r (s) = 0.280, p < 0.001) and 3 months after therapy (r (s) = 0.341, p = 0.003). There was a negative association with free T4 (FT4) (r (s) = -0.426, p < 0.001) and free triiodothyronine (FT3) (r (s) = -0.467, p = 0.038) levels at 6 months after ATDs discontinuation. In multiple-regression analysis, only duration of the first ATDs course for more than 24 months independently predicted duration of remission. Female gender, non-smoking, the absence of orbitopathy, treatment duration, pharmaceutical hypothyroidism, higher TSH levels during, at the end and 3 months after ATDs discontinuation, and lower FT4 and FT3 levels 6 months after therapy were associated with longer duration of remission. However, only duration of ATDs therapy for more than 24 months independently predicted predict long-term remission in GD.
Authors:
Panagiotis Anagnostis; Fotini Adamidou; Stergios A Polyzos; Simoni Katergari; Eleni Karathanasi; Chrisanthi Zouli; Athanasios Panagiotou; Marina Kita
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-11
Journal Detail:
Title:  Endocrine     Volume:  -     ISSN:  1559-0100     ISO Abbreviation:  Endocrine     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9434444     Medline TA:  Endocrine     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Endocrinology, Hippokration Hospital of Thessaloniki, 10 Sarantaporou Street, 54 640, Thessaloniki, Greece, anagnwstis.pan@yahoo.gr.
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