| Predictors of long-term remission in patients with Graves' disease: a single center experience. | |
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MedLine Citation:
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PMID: 23397523 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Antithyroid drugs (ATDs) remain the first-line therapy in patients with Graves' disease (GD), despite a high relapse rate. The purpose of this study was to identify the predictors of remission in patients with GD treated with ATDs-retrospective study at an endocrine referral service in Northern Greece. Two-hundred and eleven patients met the study's criteria. Females (p = 0.049), non-smokers (p = 0.017), patients without ophthalmopathy (p = 0.033), and those developing pharmaceutical hypothyroidism (p = 0.018) experienced longer duration of remission. Duration of remission was positively associated with therapy duration (r (s) = 0.151, p = 0.030), maximum TSH levels during (r (s) = 0.241, p = 0.001), at the end (r (s) = 0.280, p < 0.001) and 3 months after therapy (r (s) = 0.341, p = 0.003). There was a negative association with free T4 (FT4) (r (s) = -0.426, p < 0.001) and free triiodothyronine (FT3) (r (s) = -0.467, p = 0.038) levels at 6 months after ATDs discontinuation. In multiple-regression analysis, only duration of the first ATDs course for more than 24 months independently predicted duration of remission. Female gender, non-smoking, the absence of orbitopathy, treatment duration, pharmaceutical hypothyroidism, higher TSH levels during, at the end and 3 months after ATDs discontinuation, and lower FT4 and FT3 levels 6 months after therapy were associated with longer duration of remission. However, only duration of ATDs therapy for more than 24 months independently predicted predict long-term remission in GD. |
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Authors:
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Panagiotis Anagnostis; Fotini Adamidou; Stergios A Polyzos; Simoni Katergari; Eleni Karathanasi; Chrisanthi Zouli; Athanasios Panagiotou; Marina Kita |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-2-11 |
Journal Detail:
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Title: Endocrine Volume: - ISSN: 1559-0100 ISO Abbreviation: Endocrine Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-2-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9434444 Medline TA: Endocrine Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Endocrinology, Hippokration Hospital of Thessaloniki, 10 Sarantaporou Street, 54 640, Thessaloniki, Greece, anagnwstis.pan@yahoo.gr. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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