Document Detail

Predictors of long-term outcome in very preterm infants: gestational age versus neonatal cranial ultrasound.
MedLine Citation:
PMID:  14595054     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To investigate the effect of gestational age at birth on the frequency of ultrasound-detected brain lesions in infants born at <33 weeks of gestation and to investigate whether the relationship between neonatal cranial ultrasound diagnosis and neurodevelopmental outcome at 8 years of age was independent of gestational age. METHODS: Eight hundred forty-seven infants born at <33 weeks of gestation, admitted to a single tertiary referral center between 1983 and 1988, underwent serial neonatal cranial ultrasound. At 8 years of age neurodevelopmental outcome was assessed by structured neurologic examination, psychometric tests (Wechsler Intelligence Scale for Children), tests of visuomotor integration (Beery) and motor impairment (Henderson-Stott). Infants were subdivided into a group born at <28 weeks and a group born at between 28 and 32 weeks. Neurodevelopmental outcome was analyzed for each ultrasound diagnosis. RESULTS: Hemorrhagic lesions such as germinal matrix/intraventricular hemorrhage and hemorrhagic parenchymal infarction were more frequent in infants born at <28 weeks. There was no difference in the frequency of cystic periventricular leucomalacia between the 2 groups. When neurodevelopmental outcome for each ultrasound diagnosis was compared, no significant difference was found between the 2 gestational age groups. CONCLUSION: In the gestational age range studied, adverse neurodevelopmental outcome depends primarily on the type of the intracranial lesion rather than on gestational age.
Brigitte Vollmer; Simon Roth; Jenny Baudin; Ann L Stewart; Brian G R Neville; John S Wyatt
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatrics     Volume:  112     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-03     Completed Date:  2003-11-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1108-14     Citation Subset:  AIM; IM    
Department of Pediatrics, University College London Medical School, Bloomsbury Campus, London, United Kingdom.
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MeSH Terms
Brain Damage, Chronic / epidemiology*,  etiology,  ultrasonography
Cerebral Hemorrhage / complications,  epidemiology,  ultrasonography
Cerebral Infarction / complications,  epidemiology,  ultrasonography
Developmental Disabilities / epidemiology*,  etiology,  ultrasonography
Follow-Up Studies
Gestational Age
Infant, Newborn
Infant, Premature*
Leukomalacia, Periventricular / complications,  epidemiology,  ultrasonography
Prospective Studies
Psychomotor Performance

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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