| Predictors of an increased risk of future hypertension in Utah. A screening analysis. | |
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MedLine Citation:
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PMID: 2045178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A prospective study on 1,482 adult members of 98 Utah pedigrees was carried out to determine which variables may be associated with an increased risk of hypertension incidence. After an average of 7 years of follow-up, 40 individuals had been placed on antihypertensive medications to lower blood pressure. Baseline study variables included anthropometrics, clinical chemistry measurements of blood and urine, socioeconomic and lifestyle variables, and detailed erythrocyte ion transport and concentration measurements. Age (relative risk of 4.28 for a 2 SD difference, p less than 0.0001) and baseline systolic and diastolic blood pressures (relative risks of 3.55 and 3.52, respectively, both p less than 0.0001) had the strongest associations with hypertension incidence. Controlling for age and baseline blood pressure, the following age- and sex-adjusted variables were associated with an increased risk of future hypertension (relative risks for a 2 SD difference, all p less than 0.10): family history of hypertension (2.35); height (1.97); body mass index (2.31); abdominal girth (2.66); subscapular, suprailiac, and triceps skinfold thicknesses (2.79, 2.52, and 2.28, respectively); percent ideal body weight (2.63); log triglyceride concentration (2.02); plasma uric acid (2.16); inorganic phosphate (0.50); and passive erythrocyte sodium permeability (1.59). The final model,which included all of the age- and sex-adjusted variables (p less than 0.10) in a backward elimination logistic regression analysis, consisted of age (4.78), systolic blood pressure (2.91), subscapular skinfold thickness (2.21), height (1.92), uric acid (2.06), inorganic phosphate (0.50), and family history of hypertension (1.82). None of the ion transport or concentration measurements ws associated with an increased risk of hypertension.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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S C Hunt; S H Stephenson; P N Hopkins; R R Williams |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Hypertension Volume: 17 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1991 Jun |
Date Detail:
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Created Date: 1991-07-12 Completed Date: 1991-07-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 969-76 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure Body Mass Index Female Forecasting Humans Hypertension / etiology*, genetics Male Middle Aged Phosphates / blood Prospective Studies Regression Analysis Risk Factors Triglycerides / blood Uric Acid / blood |
| Grant Support | |
ID/Acronym/Agency:
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HL-21088/HL/NHLBI NIH HHS; HL-24855/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Phosphates; 0/Triglycerides; 69-93-2/Uric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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