Document Detail

Predictors of increased left ventricular filling pressure in dialysis patients with preserved left ventricular ejection fraction.
MedLine Citation:
PMID:  20017222     Owner:  NLM     Status:  MEDLINE    
AIM: To study the left and right ventricular function and to assess the predictors of increased left ventricular (LV) filling pressure in dialysis patients with preserved LV ejection fraction.
METHODS: This study included 63 consecutive patients (age 57+/-14 years, 57% women) with end-stage renal failure. Echocardiography, including tissue Doppler measurements, was performed in all patients. Based on the median value of the ratio of transmitral early diastolic velocity to early myocardial velocity (E/E' ratio), patients were divided into 2 groups: the group with high filling pressure (E/E'>10.16) and the group with low filling pressure (E/E'< or =10.16).
RESULTS: Compared with patients with low filling pressure, the group of patients with high filling pressure included a higher proportion of diabetic patients (41% vs 13%, P=0.022) and had greater LV mass index (211+/-77 vs 172+/-71 g/m3, P=0.04), lower LV lateral long axis amplitude (1.4+/-0.3 vs 1.6+/-0.3 cm, P=0.01), lower E wave (84+/-19 vs 64+/-18cm/s, P<0.001), higher systolic myocardial velocity (S': 8.6+/-1. 5 vs 7.0+/-1.3 cm/s, P<0.001), and lower diastolic myocardial velocities (E': 6.3+/-1.9 vs 9.5+/-2.9 cm/s, P<0.001; A': 8.4+/-1.9 vs 9.7+/-2.5 cm/s, P=0.018). Multivariate analysis identified LV systolic myocardial velocity - S' wave (adjusted odds ratio, 1.909; 95% confidence interval, 1.060-3.439; P=0.031) and age (1.053; 1.001-1.108; P=0.048) as the only independent predictors of high LV filling pressure in dialysis patients.
CONCLUSIONS: In dialysis patients with preserved left ventricular ejection fraction, reduced systolic myocardial velocity and elderly age are independent predictors of increased left ventricular filling pressure.
Gani Bajraktari; Mimoza Berbatovci-Ukimeraj; Ali Hajdari; Lavdim Ibraimi; Irfan Daullxhiu; Ymer Elezi; Gjin Ndrepepa
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Croatian medical journal     Volume:  50     ISSN:  1332-8166     ISO Abbreviation:  Croat. Med. J.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-17     Completed Date:  2010-02-24     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  9424324     Medline TA:  Croat Med J     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  543-9     Citation Subset:  IM    
Service of Cardiology, Clinic of Internal Medicine, University Clinical Centre of Kosova, Rrethi i Spitalit, p.n. 10000 Prishtina, Kosovo.
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MeSH Terms
Age Factors
Heart Failure / physiopathology
Heart Ventricles / physiopathology*
Kidney Failure, Chronic / physiopathology*,  therapy
Middle Aged
Renal Dialysis*
Stroke Volume / physiology*
Ventricular Function, Left / physiology*
Ventricular Pressure / physiology*

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