| Predictors of impaired glucose regulation in patients with non-alcoholic fatty liver disease. | |
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MedLine Citation:
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PMID: 21960993 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION. Many patients with non-alcoholic fatty liver disease (NAFLD) have impaired glucose regulation or type 2 diabetes mellitus (DM). We investigated characteristics of NAFLD patients associated with hyperglycemia. METHODS. During a 2-hour oral glucose tolerance test (OGTT), serum glucose and insulin were measured in 152 NAFLD patients. RESULTS. 48.7% of NAFLD patients had hyperglycemia. Age (odds ratio (OR) = 1.08, 95% confidence interval (CI): 1.03-1.13), body mass index (BMI) (OR = 1.12, 95% CI: 1.01-1.25), and lower high-density lipoprotein cholesterol (HDL-C) (OR = 0.95, 95% CI: 0.92-0.98) proved to be independent predictors of hyperglycemia. After OGTT, 30 min insulin was lower in hyperglycemic patients (74.2 ± 49.7 versus 94.5 ± 53.9 μIU/mL, P = 0.02), while 90 min insulin (170.1 ± 84.6 versus 122.9 ± 97.7 μU/mL, P = 0.01) and 120 min insulin (164.0 ± 101.2 versus 85.3 ± 61.9 μIU/mL, P < 0.01) were higher. CONCLUSIONS. NAFLD patients with higher BMI, lower HDL-C, or older age were more likely to have impaired glucose metabolism. An OGTT could be of value for early diagnosis of DM among this population. |
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Authors:
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Erifili Hatziagelaki; Drosos E Karageorgopoulos; Athina Chounta; Anastasia Tsiavou; Matthew E Falagas; George Dimitriadis |
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Publication Detail:
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Type: Journal Article Date: 2011-09-21 |
Journal Detail:
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Title: Experimental diabetes research Volume: 2012 ISSN: 1687-5303 ISO Abbreviation: Exp Diabetes Res Publication Date: 2012 |
Date Detail:
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Created Date: 2011-09-30 Completed Date: 2012-01-16 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 101274844 Medline TA: Exp Diabetes Res Country: United States |
Other Details:
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Languages: eng Pagination: 351974 Citation Subset: IM |
Affiliation:
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2nd Department of Internal Medicine, Research Institute and Diabetes Center, University of Athens Medical School, Attikon University Hospital, Greece. erihat@otenet.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Blood Glucose / metabolism* Body Mass Index Cholesterol, HDL / blood Cohort Studies Diabetes Mellitus, Type 2 / blood, etiology, pathology Fatty Liver / blood*, complications, pathology Female Glucose Tolerance Test Humans Hyperglycemia / blood, complications, pathology Insulin / blood Male Middle Aged Prospective Studies Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Cholesterol, HDL; 0/Insulin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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