Document Detail


Predictors of hypertension. Population studies.
MedLine Citation:
PMID:  1789936     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A genetic influence on the variability of blood pressure in populations has been established. This effect has been demonstrated repeatedly by the presence of familial aggregation of blood pressure; however, a unique bimodal distribution in populations has not been established. About one-third to one-half of the blood pressure variance is explained by heredity with the remainder due to environmental or unknown factors. Direct associations of blood pressure with genetic markers in populations have been described infrequently. However, an association between haptoglobin 1 and increased blood pressure has been reported. This relationship is possibly secondary to increased sodium sensitivity in this genetic subgroup. The familial aggregation of urinary kallikrein as well as sodium-lithium countertransport and hypertension represents a successful attempt by investigators to identify correlates of intermediate phenotypes of hypertension. The association between restriction fragment length polymorphisms and elevated blood pressure represents an unmet potential. It should be emphasized that any genetic predictive factor will be affected by environmental factors. This interaction provides the opportunity for possible modification or prevention of hypertension by hygienic means.
Authors:
R J Havlik
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American journal of hypertension     Volume:  4     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1992-03-31     Completed Date:  1992-03-31     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  586S-589S     Citation Subset:  IM    
Affiliation:
National Institute on Aging, National Institutes of Health, Bethesda, MD.
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MeSH Terms
Descriptor/Qualifier:
Genetics, Population
Humans
Hypertension / epidemiology*,  genetics*
Predictive Value of Tests

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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