Document Detail


Predictors of high sensitivity C-reactive protein levels in patients with systemic lupus erythematosus.
MedLine Citation:
PMID:  18250134     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite the increased prevalence of cardiovascular disease in patients with systemic lupus erythematosus (SLE), little is known about the role of high sensitivity C-reactive protein (hsCRP) or whether ethnicity, gender, anthropometric measures and treatment can alter hsCRP levels. We evaluated the effects of treatment and demographic, anthropometric and socio-economic variables on hsCRP levels in SLE. High sensitivity C-reactive protein levels were measured using an immunoturbidimetric assay in 610 patients from the Hopkins Lupus Cohort, who were followed-up regularly. In stepwise multiple regression analyses, body mass index (BMI) [odds ratio (OR) 1.72, 95% confidence interval (CI) 1.34-2.20, P < 0.001], African-American ethnicity (OR 1.97, 95% CI 1.22-3.19, P < 0.01), education (OR 0.60, 95% CI 0.42-0.86, P < 0.01), statin use (OR 0.38, 95% CI 0.18-0.82, P < 0.05), estrogen use (OR 3.65, 95% CI 1.19-11.22, P < 0.05), SLE Disease Activity Index score (OR 1.76, 95% CI 1.09-2.87, P < 0.05) and cumulative prednisone dose (OR 1.27, 95% CI 1.01-1.60, P < 0.05) were significant predictors of hsCRP levels. These findings suggest that hsCRP levels should be adjusted for BMI, ethnicity, education level, disease activity and medications when conducting cardiovascular risk assessment in patients with lupus.
Authors:
S-S Lee; S Singh; L S Magder; M Petri
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Lupus     Volume:  17     ISSN:  0961-2033     ISO Abbreviation:  Lupus     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-05     Completed Date:  2008-05-07     Revised Date:  2011-03-11    
Medline Journal Info:
Nlm Unique ID:  9204265     Medline TA:  Lupus     Country:  England    
Other Details:
Languages:  eng     Pagination:  114-23     Citation Subset:  IM    
Affiliation:
Department of Rheumatology, Chonnam National University Medical School, Gwangju, South Korea.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / therapeutic use
Adult
African Continental Ancestry Group
Body Mass Index*
C-Reactive Protein / metabolism*
Cardiovascular Diseases / drug therapy,  etiology*
Cohort Studies
Cross-Sectional Studies
Educational Status
Female
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
Life Style
Lupus Erythematosus, Systemic / blood*,  complications*,  therapy
Male
Middle Aged
Predictive Value of Tests
Prospective Studies
Regression Analysis
Risk Factors
Severity of Illness Index
Grant Support
ID/Acronym/Agency:
AR43727/AR/NIAMS NIH HHS; MO1-RR-00052/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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