Document Detail

Predictors of failure to complete tuberculosis treatment in London, 2003-2006.
MedLine Citation:
PMID:  20937180     Owner:  NLM     Status:  MEDLINE    
SETTING: London, 2003-2006.
OBJECTIVES: To investigate tuberculosis (TB) treatment completion failure in London and associated risk factors during 2003-2006.
DESIGN: Cross-sectional analysis of treatment outcome and other explanatory variables in a cohort of TB patients reported to the London TB Register from 2003 to 2006.
METHODS: An innovative definition of TB treatment outcome more suitable for low-incidence industrialised countries, such as the United Kingdom, was adopted. A multivariable logistic approach was used to assess predictors of unsuccessful outcome.
RESULTS: A total of 12,929 TB cases were notified from 2003 to 2006, of which 12% (n = 1536) failed to complete TB treatment. The proportion of cases failing to complete treatment showed a significant decrease from 2003 to 2006 (13% in 2003 vs. 10% in 2006). Males, the elderly, hospitalised patients, short- and long-term immigrants, Whites and the least deprived were more likely to fail to complete treatment.
CONCLUSIONS: The proportion of TB treatment success in London exceeded the World Health Organization recommended threshold of 85%. Some specific categories of patients that are more likely to fail to complete treatment should be targeted by health services to enhance their engagement and adherence to the treatment regimen.
L Cegolon; H Maguire; G Mastrangelo; J Carless; M E Kruijshaar; N Q Verlander
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease     Volume:  14     ISSN:  1815-7920     ISO Abbreviation:  Int. J. Tuberc. Lung Dis.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-12     Completed Date:  2011-01-27     Revised Date:  2011-03-30    
Medline Journal Info:
Nlm Unique ID:  9706389     Medline TA:  Int J Tuberc Lung Dis     Country:  France    
Other Details:
Languages:  eng     Pagination:  1411-7     Citation Subset:  IM    
London Regional Epidemiology Unit, Health Protection Agency, London, UK.;
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MeSH Terms
Age Factors
Antitubercular Agents / therapeutic use
Child, Preschool
Cross-Sectional Studies
Follow-Up Studies
Logistic Models
Middle Aged
Multivariate Analysis
Risk Factors
Sex Factors
Treatment Outcome
Treatment Refusal*
Tuberculosis / drug therapy*
Young Adult
Reg. No./Substance:
0/Antitubercular Agents
Erratum In:
Int J Tuberc Lung Dis. 2011 Mar;15(3):426

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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