Document Detail


Predictors of failure to complete tuberculosis treatment in London, 2003-2006.
MedLine Citation:
PMID:  20937180     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
SETTING: London, 2003-2006.
OBJECTIVES: To investigate tuberculosis (TB) treatment completion failure in London and associated risk factors during 2003-2006.
DESIGN: Cross-sectional analysis of treatment outcome and other explanatory variables in a cohort of TB patients reported to the London TB Register from 2003 to 2006.
METHODS: An innovative definition of TB treatment outcome more suitable for low-incidence industrialised countries, such as the United Kingdom, was adopted. A multivariable logistic approach was used to assess predictors of unsuccessful outcome.
RESULTS: A total of 12,929 TB cases were notified from 2003 to 2006, of which 12% (n = 1536) failed to complete TB treatment. The proportion of cases failing to complete treatment showed a significant decrease from 2003 to 2006 (13% in 2003 vs. 10% in 2006). Males, the elderly, hospitalised patients, short- and long-term immigrants, Whites and the least deprived were more likely to fail to complete treatment.
CONCLUSIONS: The proportion of TB treatment success in London exceeded the World Health Organization recommended threshold of 85%. Some specific categories of patients that are more likely to fail to complete treatment should be targeted by health services to enhance their engagement and adherence to the treatment regimen.
Authors:
L Cegolon; H Maguire; G Mastrangelo; J Carless; M E Kruijshaar; N Q Verlander
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease     Volume:  14     ISSN:  1815-7920     ISO Abbreviation:  Int. J. Tuberc. Lung Dis.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-12     Completed Date:  2011-01-27     Revised Date:  2011-03-30    
Medline Journal Info:
Nlm Unique ID:  9706389     Medline TA:  Int J Tuberc Lung Dis     Country:  France    
Other Details:
Languages:  eng     Pagination:  1411-7     Citation Subset:  IM    
Affiliation:
London Regional Epidemiology Unit, Health Protection Agency, London, UK. l.cegolon@gmail.com; l.cegolon10@imperial.ac.uk
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Aged
Antitubercular Agents / therapeutic use
Child
Child, Preschool
Cross-Sectional Studies
Female
Follow-Up Studies
Humans
Infant
Logistic Models
London
Male
Middle Aged
Multivariate Analysis
Registries
Risk Factors
Sex Factors
Treatment Outcome
Treatment Refusal*
Tuberculosis / drug therapy*
Young Adult
Chemical
Reg. No./Substance:
0/Antitubercular Agents
Comments/Corrections
Erratum In:
Int J Tuberc Lung Dis. 2011 Mar;15(3):426

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Delay in diagnosis of pulmonary tuberculosis at a primary health clinic in Vitoria, Brazil.
Next Document:  Risk of relapse and failure after retreatment with the Category II regimen in Nepal.