Document Detail

Predictors of early saphenous vein aortocoronary bypass graft occlusion. The GESIC Study Group.
MedLine Citation:
PMID:  8239808     Owner:  NLM     Status:  MEDLINE    
To identify factors determining early saphenous vein aortocoronary bypass occlusion, we analyzed the data base of the GESIC study, a trial comparing antiplatelet drug regimens that included 927 patients with 1,854 saphenous vein grafts. The univariate analysis showed female sex (p < 0.0097), obesity (p < 0.001), rest angina (p < 0.0026), history of congestive heart failure (p < 0.037), the revascularized artery (p < 0.0001), the quality of distal bed (p < 0.00001), the diameter of the grafted vessel (p < 0.00001), the lack of antiaggregant treatment (p < 0.017), and a nonsequential technique (p < 0.0002) as predictors of early (28 days) graft occlusion. In the multivariate analysis the last five variables were independent predictors. Using the two preoperative variables, it was possible to identify groups at different risk; the occlusion rate ranged between 8.79% (left anterior descending coronary artery and good distal vessel) and 27.58% (right coronary artery or left circumflex coronary artery and poor distal vessel). The combination of three variables (grafted vessel, artery diameter, and antiaggregant treatment) also allowed identification of different risk groups; the occlusion rate ranged between 3.5% and 63.1%. Thus, it is possible to anticipate the risk of graft occlusion in patients undergoing coronary artery bypass grafting, which may help in the selection of both patients and antithrombotic treatment.
M A Paz; J Lupon; X Bosch; J L Pomar; G Sanz
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  56     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1993-12-13     Completed Date:  1993-12-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1101-6     Citation Subset:  AIM; IM    
Department of Cardiology, Hospital Clinic, University of Barcelona, Spain.
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MeSH Terms
Coronary Artery Bypass*
Double-Blind Method
Graft Occlusion, Vascular / epidemiology,  etiology*,  physiopathology,  prevention & control
Middle Aged
Multivariate Analysis
Platelet Aggregation Inhibitors / therapeutic use
Predictive Value of Tests
Regression Analysis
Retrospective Studies
Risk Factors
Saphenous Vein / anatomy & histology,  radiography,  transplantation*
Time Factors
Vascular Patency
Reg. No./Substance:
0/Platelet Aggregation Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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