Document Detail


Predictors of carotid endarterectomy in middle-aged individuals.
MedLine Citation:
PMID:  11530969     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective was to investigate which screening variables in a population study predicted carotid endarterectomy. Among 793 carotid endarterectomies performed at Malmö University Hospital between 1991 and 1998, 85 patients (14 females) were identified that had participated in a population screening between 1974 and 1991. Median time from screening to operation was 16 years (range 6-26 years). Screening variables were compared with corresponding values from the background screening population (n = 33261). As operated patients were older than the background population at screening (49 [37-60] vs. 46 [26-61] years; p < 0.0001), comparisons were age-adjusted. Operated patients had higher systolic blood pressure (SBP; 130 [126-133] vs. 125 [125-125] mmHg; p < 0.01), serum total cholesterol (6.1 [5.9-6.3] vs. 5.7 [5.7-5.7] mmol/l; p < 0.0001), serum triglyceride (1.4 [1.3-1.6] vs. 1.1 [1.1-1.1] mmol/l; p < 0.0001), serum glutamic acid transferase (0.46 [0.40-0.53] vs. 0.40 [0.40-0.41] microkat/l; p < 0.05), and plasma fibrinogen (3.77 [3.42-4.16] vs. 3.35 [3.30-3.41] mmol/l; p < 0.05) levels, a lower 120-min insulin/glucose ratio at an oral glucose tolerance test (OGTT; 0.48 [0.38-0.58] vs. 0.60 [0.59-0.61]; p < 0.05) and forced vital lung capacity (3.7 [3.6-3.9] vs. 3.9 [3.9-4.0] l/min; p < 0.05), and a higher prevalence of smoking at screening (68% vs. 45%; p < 0.0001). Smoking, SBP, serum total cholesterol, and the 120-min insulin/glucose ratio remained independent predictors for carotid surgery in multivariate analysis. No differences existed among patients operated on because of symptomatic and asymptomatic stenosis. In conclusion, increased SBP and total cholesterol, lower 2-h insulin/glucose ratio at an OGTT, and smoking predict carotid surgery at long-term follow-up.
Authors:
J Forsblad; A Gottsäter; T Mätzsch; F Lindgärde
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Vascular medicine (London, England)     Volume:  6     ISSN:  1358-863X     ISO Abbreviation:  Vasc Med     Publication Date:  2001  
Date Detail:
Created Date:  2001-09-03     Completed Date:  2002-01-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9610930     Medline TA:  Vasc Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  81-5     Citation Subset:  IM    
Affiliation:
University of Lund, Department of Vascular Diseases, Malmö University Hospital, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Acyltransferases / blood
Adult
Blood Glucose / analysis
Blood Pressure / physiology
Carotid Artery, Internal / surgery
Carotid Stenosis / blood,  surgery
Endarterectomy, Carotid*
Female
Follow-Up Studies
Glucose Tolerance Test
Humans
Insulin / blood
Lipids / blood
Male
Middle Aged
Multivariate Analysis
Predictive Value of Tests
Risk Factors
Sweden / epidemiology
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Lipids; 11061-68-0/Insulin; EC 2.3.-/Acyltransferases; EC 2.3.1.14/glutamine phenylacetyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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