| Predictors of carotid endarterectomy in middle-aged individuals. | |
| | |
MedLine Citation:
|
PMID: 11530969 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The objective was to investigate which screening variables in a population study predicted carotid endarterectomy. Among 793 carotid endarterectomies performed at Malmö University Hospital between 1991 and 1998, 85 patients (14 females) were identified that had participated in a population screening between 1974 and 1991. Median time from screening to operation was 16 years (range 6-26 years). Screening variables were compared with corresponding values from the background screening population (n = 33261). As operated patients were older than the background population at screening (49 [37-60] vs. 46 [26-61] years; p < 0.0001), comparisons were age-adjusted. Operated patients had higher systolic blood pressure (SBP; 130 [126-133] vs. 125 [125-125] mmHg; p < 0.01), serum total cholesterol (6.1 [5.9-6.3] vs. 5.7 [5.7-5.7] mmol/l; p < 0.0001), serum triglyceride (1.4 [1.3-1.6] vs. 1.1 [1.1-1.1] mmol/l; p < 0.0001), serum glutamic acid transferase (0.46 [0.40-0.53] vs. 0.40 [0.40-0.41] microkat/l; p < 0.05), and plasma fibrinogen (3.77 [3.42-4.16] vs. 3.35 [3.30-3.41] mmol/l; p < 0.05) levels, a lower 120-min insulin/glucose ratio at an oral glucose tolerance test (OGTT; 0.48 [0.38-0.58] vs. 0.60 [0.59-0.61]; p < 0.05) and forced vital lung capacity (3.7 [3.6-3.9] vs. 3.9 [3.9-4.0] l/min; p < 0.05), and a higher prevalence of smoking at screening (68% vs. 45%; p < 0.0001). Smoking, SBP, serum total cholesterol, and the 120-min insulin/glucose ratio remained independent predictors for carotid surgery in multivariate analysis. No differences existed among patients operated on because of symptomatic and asymptomatic stenosis. In conclusion, increased SBP and total cholesterol, lower 2-h insulin/glucose ratio at an OGTT, and smoking predict carotid surgery at long-term follow-up. |
| | |
Authors:
|
J Forsblad; A Gottsäter; T Mätzsch; F Lindgärde |
Related Documents
:
|
23378769 - Efficacy of vildagliptin in combination with insulin in patients with type 2 diabetes a... 23147019 - Diabetes in the competitive athlete. 23264289 - Self-monitoring of blood glucose in noninsulin-using type 2 diabetic patients: it is ti... 22952989 - Health related quality of life in patients with type 2 diabetes mellitus in iran: a nat... 23190059 - Impact of diabetes mellitus on angiographic and clinical outcomes after early generatio... 17608779 - Patient time requirements for screening colonoscopy. 1320179 - A combination of the aldose reductase inhibitor, statil, and the prostaglandin e1 analo... 15117579 - Cardiac and vascular function in adolescents and young adults with type 1 diabetes. 2525209 - Prednisone, azathioprine, and cyclosporine a toxicity on human fetal pancreas. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Vascular medicine (London, England) Volume: 6 ISSN: 1358-863X ISO Abbreviation: Vasc Med Publication Date: 2001 |
Date Detail:
|
Created Date: 2001-09-03 Completed Date: 2002-01-10 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9610930 Medline TA: Vasc Med Country: England |
Other Details:
|
Languages: eng Pagination: 81-5 Citation Subset: IM |
Affiliation:
|
University of Lund, Department of Vascular Diseases, Malmö University Hospital, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acyltransferases
/
blood Adult Blood Glucose / analysis Blood Pressure / physiology Carotid Artery, Internal / surgery Carotid Stenosis / blood, surgery Endarterectomy, Carotid* Female Follow-Up Studies Glucose Tolerance Test Humans Insulin / blood Lipids / blood Male Middle Aged Multivariate Analysis Predictive Value of Tests Risk Factors Sweden / epidemiology |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 0/Lipids; 11061-68-0/Insulin; EC 2.3.-/Acyltransferases; EC 2.3.1.14/glutamine phenylacetyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Claudication does not always precede critical leg ischemia.
Next Document: The Minnesota Regional Peripheral Arterial Disease Screening Program: toward a definition of communi...