Document Detail


Predictors of cardiovascular fitness in sedentary men.
MedLine Citation:
PMID:  19370039     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The relative contribution of anthropometric and skeletal muscle characteristics to cardiorespiratory fitness was studied in sedentary men. Cardiorespiratory fitness (maximal oxygen consumption) was assessed using an incremental bicycle ergometer protocol in 37 men aged 34-53 years. Vastus lateralis muscle biopsy samples were used to assess fiber type composition (I, IIA, IIX) and areas, capillary density, and activities of glycolytic and oxidative energy metabolic pathway enzymes. Correlations (all p < 0.05) were observed between maximal oxygen consumption (L.min-1) and body mass (r = 0.53), body mass index (r = 0.39), waist circumference (r = 0.34), fat free mass (FFM; r = 0.68), fat mass (r = 0.33), the enzyme activity of cytochrome c oxidase (COX; r = 0.39), muscle type IIA (r = 0.40) and IIX (r = 0.50) fiber area, and the number of capillaries per type IIA (r = 0.39) and IIX (r = 0.37) fiber. When adjusted for FFM in partial correlations, all correlations were lost, with the exception of COX (r = 0.48). Stepwise multiple regression revealed that maximal oxygen consumption was independently predicted by FFM, COX activity, mean capillary number per fiber, waist circumference, and, to a lesser extent, muscle capillary supply. In the absence of regular physical activity, cardiorespiratory fitness is strongly predicted by the potential for aerobic metabolism of skeletal muscle and negatively correlated with abdominal fat deposition.
Authors:
Marie-Eve Riou; Etienne Pigeon; Josée St-Onge; Angelo Tremblay; André Marette; S John Weisnagel; Denis R Joanisse
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme     Volume:  34     ISSN:  1715-5312     ISO Abbreviation:  -     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-16     Completed Date:  2009-06-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264333     Medline TA:  Appl Physiol Nutr Metab     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  99-106     Citation Subset:  IM    
Affiliation:
Division of Kinesiology, Laval University, Quebec, QCG1K7P4, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adiposity
Adult
Biopsy
Body Mass Index
Capillaries / physiopathology
Cardiovascular System / physiopathology*
Cross-Sectional Studies
Electron Transport Complex IV / metabolism
Energy Metabolism*
Humans
Life Style*
Male
Middle Aged
Models, Biological
Muscle Contraction*
Obesity / metabolism,  physiopathology*
Oxygen Consumption*
Physical Fitness*
Quadriceps Muscle / blood supply,  metabolism,  physiopathology*
Waist Circumference
Chemical
Reg. No./Substance:
EC 1.9.3.1/Electron Transport Complex IV

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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