Document Detail

Predictors of bone mineral density in aging healthy men varies by skeletal site.
MedLine Citation:
PMID:  11907709     Owner:  NLM     Status:  MEDLINE    
Factors contributing to the pathogenesis of osteoporosis in women are well defined. However, changes in bone mineral metabolism in aging men and the role of various factors in the pathogenesis of age-related bone loss in men are less well understood. To further clarify these changes, serum and urine biochemical parameters, and lumbar spine, hip, and total body bone mineral density (BMD) were evaluated in a small sample of 45 healthy men aged 20-80 years, and multiple regression models were developed to predict age-related bone loss. Serum calcium, phosphate, albumin, creatinine clearance, osteocalcin, C-terminal propeptide of type I procollagen, log-free androgen index, dehydroepiandrosterone sulfate (DHEA-S), and androstenedione decreased with age, and serum sex hormone binding globulin and urine total and free pyridinoline increased with age. Femoral neck BMD decreased with age, but remained stable at the other sites measured. Multiple regression analysis indicated that serum phosphate, DHEA-S, and intact parathyroid hormone (PTH) predicted lumbar spine BMD. Age, serum phosphate, and PTH predicted femoral neck BMD. Urine-free deoxypyridinoline alone predicted femoral greater trochanter BMD. Weight, serum creatinine, and urine-free deoxypyridinoline predicted total body BMD. We conclude that predictor variables of bone density vary by skeletal site in healthy men. Alterations in adrenal androgens, phosphate, and PTH may be important in the pathogenesis of bone loss with aging in men.
B L Clarke; P R Ebeling; J D Jones; H W Wahner; W M O'Fallon; B L Riggs; L A Fitzpatrick
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2002-01-31
Journal Detail:
Title:  Calcified tissue international     Volume:  70     ISSN:  0171-967X     ISO Abbreviation:  Calcif. Tissue Int.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-21     Completed Date:  2002-07-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7905481     Medline TA:  Calcif Tissue Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  137-45     Citation Subset:  IM    
Division of Endocrinology and Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.
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MeSH Terms
Absorptiometry, Photon
Aged, 80 and over
Aging / metabolism*
Amino Acids / urine
Bone Density / physiology*
Cross-Sectional Studies
Dehydroepiandrosterone Sulfate / blood*
Femur Neck / physiopathology,  radiography
Middle Aged
Osteoporosis / metabolism*
Parathyroid Hormone / blood*
Phosphates / blood*
Predictive Value of Tests
Regression Analysis
Spine / physiopathology,  radiography
Grant Support
Reg. No./Substance:
0/Amino Acids; 0/Parathyroid Hormone; 0/Phosphates; 651-48-9/Dehydroepiandrosterone Sulfate; 90032-33-0/deoxypyridinoline

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