| Predictors of asymmetric dimethylarginine levels in patients with rheumatoid arthritis: the role of insulin resistance. | |
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MedLine Citation:
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PMID: 23311682 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: To determine whether demographic, inflammatory, and metabolic factors predict elevated asymmetric dimethylarginine (ADMA) levels in rheumatoid arthritis (RA). Method: A total of 67 RA patients [mean age 56 ± 12 years, median disease duration 8 (3-15) years] were assessed. Routine biochemistry tests, lipid profile, glycaemic profile [glucose, insulin, homeostasis model assessment (HOMA), quantitative insulin sensitivity check index (QUICKI)], and inflammatory markers were measured in all patients. ADMA levels were measured by enzyme-linked immunosorbent assay (ELISA). Regression analyses were performed to identify predictors of ADMA in RA. Results: Regression analysis revealed that HOMA (β = 0.149, p = 0.003) was an independent predictor of ADMA in RA. From the drug factors, anti-hypertensive medication use was associated with lower ADMA levels (β = -0.081, p = 0.004). ADMA was not associated with RA disease-related parameters or any of the other cardiovascular risk factors that were assessed. Conclusions: HOMA, a strong indicator of insulin resistance, seems to be the main predictor of elevated ADMA levels in RA patients; ADMA may reflect an important pathway linking abnormal insulin metabolism with endothelial dysfunction in RA. |
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Authors:
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T Dimitroulas; A Sandoo; Jjjcs Veldhuijzen van Zanten; Jp Smith; J Hodson; Gs Metsios; A Stavropoulos-Kalinoglou; Gd Kitas |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-14 |
Journal Detail:
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Title: Scandinavian journal of rheumatology Volume: - ISSN: 1502-7732 ISO Abbreviation: Scand. J. Rheumatol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0321213 Medline TA: Scand J Rheumatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Rheumatology, Dudley Group NHS Foundation Trust, Russells Hall Hospital , Dudley, West Midlands , UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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