| Predictors of adverse perinatal outcome in twins delivered at < 37 weeks. | |
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MedLine Citation:
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PMID: 15621553 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Multiple gestations are at increased risk for prematurity as well as perinatal mortality and morbidity. The aim of this study was to identify the independent risk factors for adverse perinatal outcome in a large uniform population of twins delivered preterm. METHODS: We accessed a cohort of twin gestations for the period 1990-2000 delivered at < 37.0 weeks gestation. Chorionicity was established by ultrasound assessment of the dividing membrane, neonatal gender and histologic examination of the placenta at birth. Adverse perinatal outcome was defined as stillbirth, neonatal death, or major neonatal complications. Statistical analysis used contingency tables, Student's t test, one-way ANOVA and logistic regression, with a two-tailed p < 0.05 considered significant. RESULTS: A total of 356 twin gestations (712 twins) were included in the database, and 183 twins (25.7%) had adverse perinatal outcome. Logistic regression analysis demonstrated that gestational age at delivery (p < 0.001), premature rupture of membranes (PROM) (p = 0.004), birth weight discordance (p = 0.009), and 5-min Apgar scores (p = 0.001) were significant and independent predictors of adverse perinatal outcome, whereas monochorionicity and twin-twin transfusion syndrome were not. CONCLUSIONS: Gestational age at delivery and birth weight discordance are the most important independent predictors of perinatal mortality or morbidity among preterm twins. |
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Authors:
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Patrizia Vergani; Anna Locatelli; Marta Ratti; Antonietta Scian; Giulia Zangheri; John Pezzullo; Alessandro Ghidini |
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2282443 - The epidemiology of perinatal mortality in multiple births. 9715553 - Growth and development of twins compared with singletons at ages one and four years. 3123693 - Fetal valproate syndrome: is there a recognisable phenotype? |
Publication Detail:
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Type: Journal Article; Twin Study |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: 16 ISSN: 1476-7058 ISO Abbreviation: J. Matern. Fetal. Neonatal. Med. Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-12-28 Completed Date: 2005-05-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: United States |
Other Details:
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Languages: eng Pagination: 343-7 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Apgar Score Birth Weight* Female Gestational Age* Humans Infant Mortality* Infant, Newborn Infant, Premature* Male Predictive Value of Tests Pregnancy Pregnancy Outcome* Risk Factors Twins* Twins, Dizygotic Twins, Monozygotic |
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