Document Detail


Predictors of abnormal heart rate recovery in patients with heart failure reduced and preserved ejection fraction.
MedLine Citation:
PMID:  23335654     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BackgroundHeart rate recovery (HRR) is becoming an important prognostic maker in heart failure (HF), but very little is known about the underlying mechanisms responsible for its clinical efficacy. Therefore, we examined echocardiographic and exercise (submaximal and maximal) characteristics to gain a better appreciation of HRR and factors responsible for the development of abnormal HRR in patients with both heart failure reduced ejection fraction (HFrEF) and heart failure preserved ejection fraction (HFpEF).MethodsCardiopulmonary exercise testing (CPX), a 6-minute walk test (6MWT), and resting 2D echocardiography were randomly performed in 240 HF patients (200 HFrEF, 40 HFpEF) after which HRR was measured. HRR was defined as the difference between heart rate at peak exercise and 1 minute following test termination.ResultsBivariate correlation analyses found significant relationships among most CPX and 6MWT measurements with the highest correlations between 6MWT HRR and 6MWT peak HR (r = 0.65; p < 0.001) and CPX HRR and CPX HR(reserve) (r = 0.63; p < 0.001). The relationship between 6MWT HRR and CPX HRR was very good (r = 0.91; p < 001). Multivariate logistic regression of submaximal and maximal exercise found 6MWT peak HR and exercise oscillatory ventilation (EOV), respectively, were the strongest predictors (p < 0.001) of abnormal HRR. The E/E' was a significant predictor (p < 0.001) of abnormal HRR, but EOV was the strongest predictor of abnormal HRR (OR = 6.5).ConclusionsHRR after both CPX and the 6MWT is significantly related to many exercise and echocardiographic measures with the most significant predictors of abnormal HRR being related to indices of cardiorespiratory performance in patients with HFrEF and HFpEF.
Authors:
Lawrence P Cahalin; Ross Arena; Valentina Labate; Francesco Bandera; Marco Guazzi
Related Documents :
21490504 - The involvement of nitric oxide and endothelin-1 in exercise-induced bronchospasm in yo...
7273494 - The effect of minimal exercise on the blood lactate in azotemic subjects.
10352804 - Lactate in sepsis and trauma--hindrance or help?
21460404 - Monitoring pulmonary function during exercise in children with asthma.
22584644 - Hemodynamic mechanisms of the attenuated blood pressure response to mental stress after...
12930184 - Different effects of concentric and eccentric muscle actions on plasma volume.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-18
Journal Detail:
Title:  European journal of preventive cardiology     Volume:  -     ISSN:  2047-4881     ISO Abbreviation:  Eur J Prev Cardiol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101564430     Medline TA:  Eur J Prev Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
University of Miami, Miami, FL, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Is the chimney graft technique a safe and feasible approach to treat urgent aneurysm and pseudoaneur...
Next Document:  Target organ damage and cardiovascular risk factors among subjects with previously undiagnosed hyper...