Document Detail

Predictors of vascular events after ischemic stroke: the China ischemic stroke registry study.
MedLine Citation:
PMID:  20051694     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: To measure the risk of vascular event occurrence among postischemic stroke patients in mainland China. METHODS: In this multicenter prospective stroke registry study, we enrolled 1,951 patients diagnosed with acute ischemic stroke. Demographic data, prestroke risk factors, severity of neurological deficits and disability graded on the National Institutes of Health Stroke Scale (NIHSS), and modified Rankin Scale scores of each patient were measured and recorded. Patients were followed up regularly for 12 months after recruitment. Clinical endpoints were defined as occurrence of vascular events or death. RESULTS: We detected 103 cases with nonfatal vascular events and 27 cases that died of vascular events. Cumulative incidences of total vascular events, cerebrovascular events, and coronary artery diseases were 7.2, 5.0, and 1.8%, respectively, at 12 months after the initial ischemic stroke. Concomitant atherosclerotic-thrombotic diseases (HR, 1.68; 95% CI, 1.14-2.43) and baseline NIHSS (HR, 1.07; 95% CI, 1.03-1.11) were found to be the best predictors for further occurrence of a vascular event. Antiplatelet therapy (HR, 0.52; 95% CI, 0.35-0.77) is associated with a lower risk of further vascular events. CONCLUSION: Our study provided valuable data on prognosis of acute ischemic stroke in Chinese patients.
Ding Ding; Chuan-Zhen Lu; Jian-Hui Fu; Zhen Hong
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2009-12-24
Journal Detail:
Title:  Neuroepidemiology     Volume:  34     ISSN:  1423-0208     ISO Abbreviation:  Neuroepidemiology     Publication Date:  2010  
Date Detail:
Created Date:  2010-02-17     Completed Date:  2010-05-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8218700     Medline TA:  Neuroepidemiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  110-6     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Institute of Neurology, WHO Collaborating Center for Research and Training in Neuroscience, Huashan Hospital, Fudan University, Shanghai, China.
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MeSH Terms
Acute Disease
Brain Ischemia / diagnosis*,  drug therapy,  mortality
Disability Evaluation
Follow-Up Studies
Middle Aged
Platelet Aggregation Inhibitors / therapeutic use
Prospective Studies
Risk Factors
Severity of Illness Index
Stroke / diagnosis*,  drug therapy,  mortality
Time Factors
Treatment Outcome
Vascular Diseases / diagnosis*,  mortality
Reg. No./Substance:
0/Platelet Aggregation Inhibitors

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