Document Detail

Predictors of tetrabromobisphenol-A (TBBP-A) and hexabromocyclododecanes (HBCD) in milk from Boston mothers.
MedLine Citation:
PMID:  22998345     Owner:  NLM     Status:  MEDLINE    
Tetrabromobisphenol-A (TBBP-A) and hexabromocyclododecanes (HBCDs) are brominated flame retardants that have been found in human milk and serum throughout the world, but have received comparatively little attention in the United States. The objective of this study is to determine concentrations of these analytes in samples of breast milk collected from first-time mothers in the Greater Boston, Massachusetts area and to explore predictors of exposure. Human milk samples were analyzed by LC-ESI-MS/MS for TBBP-A, HBCDs (the α, β, and γ diastereomers), and HBCD degradation products: pentabromocyclododecanes (PBCDs) and tetrabromocyclododecadienes (TBCDs). HBCD diastereomers were detected in all samples with α-HBCD present in the highest proportion. TBBP-A, PBCDs, and TBCDs were detected in 35%, 42%, and 56% of the analyzed samples, respectively. Self-reported demographic, dietary and behavioral data were examined as predictors of HBCD levels. Levels of HBCD were significantly, positively associated with the number of stereo and video electronics in the home (17% increase/item; 95% Confidence Interval (CI) = 4-31%) and reduced in participants who regularly chose organic foods compared to those who did not (0.51, 95% CI = 0.32-0.82). These results suggest that lifestyle factors are related to body burdens of HBCD and that domestic electronics may be an important source of HBCD exposure in the indoor environment.
Courtney C Carignan; Mohamed Abou-Elwafa Abdallah; Nerissa Wu; Wendy Heiger-Bernays; Michael D McClean; Stuart Harrad; Thomas F Webster
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-10-16
Journal Detail:
Title:  Environmental science & technology     Volume:  46     ISSN:  1520-5851     ISO Abbreviation:  Environ. Sci. Technol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-06     Completed Date:  2013-04-18     Revised Date:  2013-11-14    
Medline Journal Info:
Nlm Unique ID:  0213155     Medline TA:  Environ Sci Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  12146-53     Citation Subset:  IM    
Department of Environmental Health, Boston University School of Public Health, 715 Albany Street, Boston, Massachusetts 02118, USA.
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MeSH Terms
Environmental Monitoring
Environmental Pollutants / analysis*
Flame Retardants / analysis*
Food, Organic
Hydrocarbons, Brominated / analysis*
Milk, Human / chemistry*
Polybrominated Biphenyls / analysis*
Grant Support
Reg. No./Substance:
0/Environmental Pollutants; 0/Flame Retardants; 0/Hydrocarbons, Brominated; 0/Polybrominated Biphenyls; 25637-99-4/hexabromocyclododecane; FQI02RFC3A/tetrabromobisphenol A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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