| Predictors of response to treadmill exercise in stroke survivors. | |
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MedLine Citation:
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PMID: 20453154 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Aerobic treadmill exercise (T-EX) therapy has been shown to benefit walking and cardiorespiratory fitness in stroke survivors with chronic gait impairment even long after their stroke. The response, however, varies between individuals. OBJECTIVE: The purpose of this post hoc analysis of 2 randomized controlled T-EX trials was to identify predictors for therapy response. METHODS: In all, 52 participants received T-EX for 3 (Germany) or 6 (United States) months. Improvements in overground walking velocity (10 m/6-min walk) and fitness (peak VO(2)) were indicators of therapy response. Lesion location and volume were measured on T1-weighted magnetic resonance scans. RESULTS: T-EX significantly improved gait and fitness, with gains in 10-m walk tests ranging between +113% and -25% and peak VO(2) between -12% and 88%. Baseline walking impairments or fitness deficits were not predictive of therapy response; 10-m walk velocity improved more in those with subcortical rather than cortical lesions and in patients with smaller lesions. Improvements in 6-minute walk velocity were greater in those with more recent strokes and left-sided lesions. No variable other than training intensity, which was different between trials, predicted fitness gains. CONCLUSIONS: Despite proving overall effectiveness, the response to T-EX varies markedly between individuals. Whereas intensity of aerobic training seems to be an important predictor of gains in cardiovascular fitness, lesion size and location as well as interval between stroke onset and therapy delivery likely affect therapy response. These findings may be used to guide the timing of training and identify subgroups of patients for whom training modalities could be optimized. |
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Authors:
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Judith M Lam; Christoph Globas; Joachim Cerny; Benjamin Hertler; Kamil Uludag; Larry W Forrester; Richard F Macko; Daniel F Hanley; Clemens Becker; Andreas R Luft |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-05-07 |
Journal Detail:
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Title: Neurorehabilitation and neural repair Volume: 24 ISSN: 1552-6844 ISO Abbreviation: Neurorehabil Neural Repair Publication Date: 2010 Jul-Aug |
Date Detail:
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Created Date: 2010-06-28 Completed Date: 2011-02-15 Revised Date: 2011-07-20 |
Medline Journal Info:
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Nlm Unique ID: 100892086 Medline TA: Neurorehabil Neural Repair Country: United States |
Other Details:
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Languages: eng Pagination: 567-74 Citation Subset: IM |
Affiliation:
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University of Zürich, Zürich, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Exercise Test / instrumentation, methods* Exercise Therapy / instrumentation, methods* Female Gait / physiology Gait Disorders, Neurologic / diagnosis, physiopathology, rehabilitation* Humans Male Middle Aged Outcome Assessment (Health Care) / methods* Paresis / diagnosis, physiopathology, rehabilitation* Physical Fitness / physiology Predictive Value of Tests Prognosis Severity of Illness Index Stroke / pathology, physiopathology, rehabilitation* Treatment Outcome Walking / physiology |
| Grant Support | |
ID/Acronym/Agency:
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M01-00052//PHS HHS; P60 AG012583-10/AG/NIA NIH HHS; P60AG 12583/AG/NIA NIH HHS |
| Comments/Corrections | |
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